Distribution of a persistent sodium current across the ventricular wall in guinea pigs (Endocardial Cell)

Distribution of a persistent sodium current across the ventricular wall in guinea pigs.

Model Status

This model has been curated and unit-checked and is known to run in COR and PCEnv. This variant is parameterised for the cardiac ENDOCARDIAL CELL.

Model Structure

ABSTRACT: A tetrodotoxin-sensitive persistent sodium current, IpNa, was found in guinea pig ventricular myocytes bywhole-cell patch clamping. This current was characterized in cells derived from the basal left ventricular subendocardium,midmyocardium, and subepicardium. Midmyocardial cells show a statistically significant (P,0.05) smaller IpNathan subendocardial and subepicardial myocytes. There was no significant difference in IpNa current density betweensubepicardial and subendocardial cells. Computer modeling studies support a role of this current in the dispersion ofaction potential duration across the ventricular wall."

The original paper reference is cited below:

Distribution of a persistent sodium current across the ventricular wall in guinea pigs, Bernhard F.A.S. Sakmann, Anthony J. Spindler, Simon M. Bryant, Klaus W. Linz and Denis Noble, 2000, Circulation Research, 87, (10), 910-914. PubMed ID: 11073887

Schematic diagram of the Sakmann et al. 2000 cardiac cell model.