Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node.

Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node.

Model Status

The CellML version of this model has been curated and unit checked by Penny Noble and it is known to run in COR to recreate the published results. The Zhang model has since been updated by Alan Garny et al. (2003) and this model has also been described in CellML and can be found in the model repository.

ValidateCellML confirms this model as valid CellML with full unit consistency.

Model Structure

ABSTRACT: Mathematical models of the action potential in the periphery and center of the rabbit sinoatrial (SA) node have been developed on the basis of published experimental data. Simulated action potentials are consistent with those recorded experimentally: the model-generated peripheral action potential has a more negative takeoff potential, faster upstroke, more positive peak value, prominent phase 1 repolarization, greater amplitude, shorter duration, and more negative maximum diastolic potential than the model-generated central action potential. In addition, the model peripheral cell shows faster pacemaking. The models behave qualitatively the same as tissue from the periphery and center of the SA node in response to block of tetrodotoxin-sensitive Na(+) current, L- and T-type Ca(2+) currents, 4-aminopyridine-sensitive transient outward current, rapid and slow delayed rectifying K(+) currents, and hyperpolarization-activated current. A one-dimensional model of a string of SA node tissue, incorporating regional heterogeneity, coupled to a string of atrial tissue has been constructed to simulate the behavior of the intact SA node. In the one-dimensional model, the spontaneous action potential initiated in the center propagates to the periphery at approximately 0.06 m/s and then into the atrial muscle at 0.62 m/s.

The original paper is cited below.

Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node, H. Zhang, A.V. Holden, I. Honjo, M. Lei, T. Varghese and M.R. Boyett, 2000, American Journal of Physiology, 279, H397-H421. PubMed ID: 10899081

A schematic diagram describing the current flows across the cell membrane that are captured in the Zhang et al 2000 model of the action potentials in the peripheral cells of the SA node.
Model Curation
  • Curation Status c1
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  • COR c2
  • OpenCell c2
Source
Derived from workspace Zhang, Holden, Kodama, Honjo, Lei, Varghese, Boyett, 2000 at changeset ab4ddd874c7d.
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License

This work is licensed under a Creative Commons Attribution 3.0 Unported License.