Model Mathematics

Component: environment

Component: nucleus

ddtimeM_P=v_sPK_IPnK_IPn+C_Nn-v_mPM_PK_mP+M_P-k_dM_P ddtimeM_T=v_sTK_ITnK_ITn+C_Nn-v_mTM_TK_mT+M_T-k_dM_T ddtimeC_N=k_1C-k_2C_N-k_dNC_N

Component: cytosol

ddtimeC=k_3P_2T_2-k_4C-k_1C+k_2C_N-k_dCC

Component: PER

ddtimeP_0=k_sPM_P-V_1PP_0K_1P+P_0+V_2PP_1K_2P+P_1-k_dP_0 ddtimeP_1=V_1PP_0K_1P+P_0-V_2PP_1K_2P+P_1-V_3PP_1K_3P+P_1+V_4PP_2K_4P+P_2-k_dP_1 ddtimeP_2=V_3PP_1K_3P+P_1-V_4PP_2K_4P+P_2-k_3P_2T_2+k_4C-v_dPP_2K_dP+P_2-k_dP_2

Component: TIM

ddtimeT_0=k_sTM_T-V_1TT_0K_1T+T_0+V_2TT_1K_2T+T_1-k_dT_0 ddtimeT_1=V_1TT_0K_1T+T_0-V_2TT_1K_2T+T_1-V_3TT_1K_3T+T_1+V_4TT_2K_4T+T_2-k_dT_1 ddtimeT_2=V_3TT_1K_3T+T_1-V_4TT_2K_4T+T_2-k_3P_2T_2+k_4C-v_dTT_2K_dT+T_2-k_dT_2

Component: PER_total

P_t=P_0+P_1+P_2+C+C_N

Component: TIM_total

T_t=T_0+T_1+T_2+C+C_N