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Leloup, Goldbeter,
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A Model for Circadian Rhythms in Drosophila Incorporating the Formation of a Complex between the PER and TIM Proteins (Continuous Darkness Model)
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Model Mathematics
Component based math viewer is available
Component: environment
Component: nucleus
d
d
time
M_P
=
v_sP
K_IP
n
K_IP
n
+
C_N
n
-
v_mP
M_P
K_mP
+
M_P
-
k_d
M_P
d
d
time
M_T
=
v_sT
K_IT
n
K_IT
n
+
C_N
n
-
v_mT
M_T
K_mT
+
M_T
-
k_d
M_T
d
d
time
C_N
=
k_1
C
-
k_2
C_N
-
k_dN
C_N
Component: cytosol
d
d
time
C
=
k_3
P_2
T_2
-
k_4
C
-
k_1
C
+
k_2
C_N
-
k_dC
C
Component: PER
d
d
time
P_0
=
k_sP
M_P
-
V_1P
P_0
K_1P
+
P_0
+
V_2P
P_1
K_2P
+
P_1
-
k_d
P_0
d
d
time
P_1
=
V_1P
P_0
K_1P
+
P_0
-
V_2P
P_1
K_2P
+
P_1
-
V_3P
P_1
K_3P
+
P_1
+
V_4P
P_2
K_4P
+
P_2
-
k_d
P_1
d
d
time
P_2
=
V_3P
P_1
K_3P
+
P_1
-
V_4P
P_2
K_4P
+
P_2
-
k_3
P_2
T_2
+
k_4
C
-
v_dP
P_2
K_dP
+
P_2
-
k_d
P_2
Component: TIM
d
d
time
T_0
=
k_sT
M_T
-
V_1T
T_0
K_1T
+
T_0
+
V_2T
T_1
K_2T
+
T_1
-
k_d
T_0
d
d
time
T_1
=
V_1T
T_0
K_1T
+
T_0
-
V_2T
T_1
K_2T
+
T_1
-
V_3T
T_1
K_3T
+
T_1
+
V_4T
T_2
K_4T
+
T_2
-
k_d
T_1
d
d
time
T_2
=
V_3T
T_1
K_3T
+
T_1
-
V_4T
T_2
K_4T
+
T_2
-
k_3
P_2
T_2
+
k_4
C
-
v_dT
T_2
K_dT
+
T_2
-
k_d
T_2
Component: PER_total
P_t
=
P_0
+
P_1
+
P_2
+
C
+
C_N
Component: TIM_total
T_t
=
T_0
+
T_1
+
T_2
+
C
+
C_N
Source
Derived from workspace
Leloup, Goldbeter, 1998
at changeset
fe901dc75450
.
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Creative Commons Attribution 3.0 Unported License
.
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A Model for Circadian Rhythms in Drosophila Incorporating the Formation of a Complex between the PER and TIM Proteins (Continuous Darkness Model)
A Model for Circadian Rhythms in Drosophila Incorporating the Formation of a Complex between the PER and TIM Proteins (Light-Dark Cycle Model)