Anode/cathode make and break phenomena in a model of defibrillation

Model Structure

The original Beeler-Reuter mammalian ventricular model (1977) (see The Beeler-Reuter Model, 1977) was modified by Drouhard and Roberge (1987) (see The Drouhard-Roberge Model, 1987) to improve the fast sodium current kinetics. This model was then further modified by Skouibine et al. (1999) to handle potentials outside the range of normal physiological activity, allowing the model to be used in defibrillation studies.

The complete original paper reference is cited below:

Anode/cathode make and break phenomena during defibrillation: Does electroporation make a difference?, Skouibine, K., Trayanova, N., Moore, P. 1999 IEEE Trans. Biomed. Eng , 46, 769-777. PubMed ID: 10396895

The raw CellML description of the defibrillation Beeler-Reuter model can be downloaded in various formats as described in . For an example of a more complete documentation for an electrophysiological model, see The Hodgkin-Huxley Squid Axon Model, 1952.