A Mathematical Model of a Rabbit Sinoatrial Node Cell

Model Status

This version of the model has been curated by Penny Noble using COR and is known to read in to PCEnv and JSim.

ValidateCellML confirms this model as valid CellML detects units inconsistencies.

Model Structure

In 1994 S.S. Demir et al published a mathematical model which describes the electrophysiological responses of a rabbit sinoatrial node cell (see the figure below). The model is based on voltage-clamp data from single, isolated myocytes. Ion channels, pumps and exchangers in the sarcolemma are described using equations for these known currents in mammalian pacemaker cells. The extracellular environment is treated as a diffusion limited space, and the myoplasm contains calcium binding proteins (calmodulin and troponin).

The complete original paper reference is cited below:

A mathematical model of a rabbit sinoatrial node cell, S.S. Demir, J.W. Clark, C.R. Murphey and W.R. Giles, 1994, American Journal of Physiology , 266, C832-C852. PubMed ID: 8166247

A schematic diagram describing the current flows across the cell membrane that are captured in the Demir et al 1994 model of the electrophysiological activity in a SA node cell.

The network defined in the CellML description of the Demir et al 1994 model. For simplicity, not all the variables are shown.