Evolution of Immunological Memory and the Regulation of Competition between Pathogens

Evolution of Immunological Memory and the Regulation of Competition between Pathogens

Model Status

This model runs in Open Cell but due to the timescale being in days it is not able to be easily graphed in COR. The model can produce output that matches figure 2A in the published paper. The units have been checked and they balance.

Model Structure

ABSTRACT: Memory is a central characteristic of immune responses. It is defined as an elevated number of specific immune cells that remain after resolution of infection and can protect the host against reinfection. The evolution of immunological memory is subject to debate. The advantages of memory discussed so far include protection from reinfection, control of chronic infection, and the transfer of immune function to the next generation. Mathematical models are used to identify a new force that can drive the evolution of immunological memory: the duration of memory can regulate the degree of competition between different pathogens. While a long duration of memory provides lasting protection against reinfection, it may also allow an inferior pathogen species to persist. This can be detrimental for the host if the inferior pathogen is more virulent. On the other hand, a shorter duration of memory ensures that an inferior pathogen species is excluded. This can be beneficial for the host if the inferior pathogen is more virulent. Thus, while in the absence of pathogen diversity memory is always expected to evolve to a long duration, under specific circumstances, memory can evolve toward shorter durations in the presence of pathogen diversity.

The original paper reference is cited below:

Evolution of Immunological Memory and the Regulation of Competition between Pathogens, Dominik Wodarz, 2003, Current Biology, 13, 1648-1652. PubMed ID: 13678598

Interactions between a single pathogen population and a host population.
Interactions between two pathogen populations and a host population.
Model Curation
  • Curation Status c2
  • JSim c0
  • COR c1
  • OpenCell c2
Source
Derived from workspace Wodarz, 2003 at changeset a16c2e1a1930.
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License

This work is licensed under a Creative Commons Attribution 3.0 Unported License.