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Katsnelson, Nikitina, Chemla, Solovyova, Coirault, Lecarpentier, Markhasin, 2004
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Influence of viscosity on myocardium mechanical activity: a mathematical model
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Model Mathematics
Component based math viewer is available
Component: environment
Component: parameters
Component: parameters_izakov_et_al_1991
q_v
=
q_1
-
q_2
v
v_max
if
v
≦
0
q_3
otherwise
v_1
=
v_max
10
Component: force
F_CE
=
lambda
p_v
N
F_muscle
=
F_XSE
F_SE
=
beta_1
ⅇ
alpha_1
l_2
-
l_1
-
1
F_PE
=
beta_2
ⅇ
alpha_2
l_2
-
1
F_XSE
=
beta_3
ⅇ
alpha_3
l_3
-
1
Component: crossbridge_kinetics
M_A
=
A
mu
A
mu
+
A_half
mu
n_1
=
0.6
l_1
+
0.5
L_oz
=
l_1
+
S_0
0.46
+
S_0
k_p_v
=
chi
chi_0
q_v
m_0
G_star
k_m_v
=
chi_0
q_v
1
-
chi
m_0
G_star
K_chi
=
k_p_v
M_A
n_1
L_oz
1
-
N
-
k_m_v
N
d
d
time
N
=
K_chi
Component: length
dl_1_dt
=
v
d
d
time
l_1
=
dl_1_dt
dl_2_dt
=
w
d
d
time
l_2
=
dl_2_dt
dl_3_dt
=
0
if
isotonic_mode
=
1
-
w
otherwise
d
d
time
l_3
=
dl_3_dt
Component: CE_velocity
k_P_vis
=
beta_P_lengthening
ⅇ
alpha_P_lengthening
l_1
if
dl_1_dt
≦
0
beta_P_shortening
ⅇ
alpha_P_shortening
l_1
otherwise
phi_chi
=
lambda
K_chi
p_v
1
+
alpha_P
k_P_vis
v
2
+
alpha_2
beta_2
ⅇ
alpha_2
l_2
w
1
lambda
N
p_prime_v
1
+
k_P_vis
if
isotonic_mode
=
1
lambda
K_chi
p_v
1
+
alpha_P
k_P_vis
v
2
+
alpha_2
beta_2
ⅇ
alpha_2
l_2
+
alpha_3
beta_3
ⅇ
alpha_3
l_3
w
1
lambda
N
p_prime_v
1
+
k_P_vis
otherwise
d
d
time
v
=
phi_chi
Component: PE_velocity
k_S_vis
=
beta_S_lengthening
ⅇ
alpha_S_lengthening
l_2
-
l_1
if
dl_2_dt
≦
dl_1_dt
beta_S_shortening
ⅇ
alpha_S_shortening
l_2
-
l_1
otherwise
d
d
time
w
=
k_S_vis
phi_chi
-
alpha_S
w
-
v
2
-
alpha_1
beta_1
ⅇ
alpha_1
l_2
-
l_1
w
-
v
1
-
alpha_2
beta_2
ⅇ
alpha_2
l_2
w
1
k_S_vis
if
isotonic_mode
=
1
k_S_vis
phi_chi
-
alpha_S
w
-
v
2
-
alpha_1
beta_1
ⅇ
alpha_1
l_2
-
l_1
w
-
v
1
-
alpha_2
beta_2
ⅇ
alpha_2
l_2
+
alpha_3
beta_3
ⅇ
alpha_3
l_3
w
1
k_S_vis
otherwise
Component: average_crossbridge_force
gamma
=
a
d_h
v_1
v_max
2
3
a
d_h
-
a
+
1
v
v_max
P_star
=
a
1
+
v
v_max
a
-
v
v_max
if
v
≦
0
1
+
d_h
-
d_h
2
a
a
d_h
gamma
v
v_max
2
+
a
+
1
v
v_max
+
a
d_h
otherwise
G_star
=
1
+
0.6
v
v_max
if
-
v_max
≦
v
∧
v
≦
0
P_star
0.4
a
+
1
a
v
v_max
+
1
if
0
<
v
∧
v
≦
v_1
P_star
ⅇ
-
alpha_G
v
-
v_1
v_max
alpha_PG
0.4
a
+
1
a
v
v_max
+
1
otherwise
case_1
=
a
0.4
+
0.4
a
v_max
a
+
1
0.4
2
case_2
=
a
1
1
+
0.4
a
+
1.2
v
v_max
+
0.6
v
v_max
2
v_max
a
-
v
v_max
1
+
0.6
v
v_max
2
case_3
=
0.4
a
+
1
a
v_max
case_4
=
1
v_max
ⅇ
-
alpha_G
v
v_max
-
v_1
v_max
alpha_PG
0.4
a
+
1
a
+
alpha_G
alpha_P
1
+
0.4
a
+
1
v
a
v_max
v
v_max
-
v_1
v_max
alpha_PG
-
1
p_v
=
P_star
G_star
p_prime_v
=
case_1
phi_chi
if
v
≦
-
v_max
case_2
phi_chi
if
-
v_max
<
v
∧
v
≦
0
case_3
phi_chi
if
0
<
v
∧
v
≦
v_1
case_4
phi_chi
otherwise
Component: calcium_handling
d
d
time
A
=
dA_dt
dA_dt
=
a_on
A_tot
-
A
Ca_C
-
a_off
ⅇ
-
k_A
A
pi_N_A
A
N_A
=
N
L_oz
A
pi_N_A
=
1
if
N_A
≥
1
0.02
N_A
otherwise
d
d
time
B
=
dB_dt
dB_dt
=
b_on
B_tot
-
B
Ca_C
-
b_off
B
d
d
time
Ca_C
=
b_c
time
1
-
ⅇ
-
a_c
time
2
ⅇ
-
a_c
time
2
if
time
<
t_d
-
dA_dt
-
dB_dt
-
r_Ca
ⅇ
-
q_Ca
Ca_C
Ca_C
otherwise
Source
Derived from workspace
Katsnelson, Nikitina, Chemla, Solovyova, Coirault, Lecarpentier, Markhasin, 2004
at changeset
5725a8a06502
.
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Influence of viscosity on myocardium mechanical activity: a mathematical model