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Tham, Wang, Soo, Lee, Lee, Yong, Goh, Holford, 2008
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A pharmacodynamic model for the time course of tumor shrinkage by gemcitabine + carboplatin in non-small cell lung cancer patients
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Model Mathematics
Component based math viewer is available
Component: environment
Exposure
=
Dose
if
time
<
Cycle_Int
N_Cycle
∧
Dose_Int1
<
rem_time
∧
rem_time
<
Dose_Length
Dose
if
time
<
Cycle_Int
N_Cycle
∧
Dose_Int2
<
rem_time
∧
rem_time
<
Dose_Int2
+
Dose_Length
0
otherwise
rem_time
=
time
conversion_factor
mod
Cycle_Int
conversion_factor
conversion_factor
Component: effect_compartment
k_1
=
ln
2
t_half_eq
d
d
time
Ce
=
Exposure
1
-
Ce
k_1
Effect
=
1
-
E_max
Ce
Amt_50
+
Ce
Component: response_compartment
RateIn
=
Size_0
k_2
k_2
=
ln
2
T_Turnover
d
d
time
Size
=
RateIn
Effect
-
k_2
Size
Size
Source
Derived from workspace
Tham 2008
at changeset
a4870ebb6200
.
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License
This work is licensed under a
Creative Commons Attribution 3.0 Unported License
.
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A pharmacodynamic model for the time course of tumor shrinkage by gemcitabine + carboplatin in non-small cell lung cancer patients