Generated Code
The following is c code generated by the CellML API from this CellML file. (Back to language selection)
The raw code is available.
/*
There are a total of 32 entries in the algebraic variable array.
There are a total of 23 entries in each of the rate and state variable arrays.
There are a total of 50 entries in the constant variable array.
*/
/*
* VOI is time in component environment (second).
* STATES[0] is EGF in component EGF (nanomolar).
* ALGEBRAIC[0] is v1 in component v1 (flux).
* STATES[1] is R in component R (nanomolar).
* STATES[2] is Ra in component Ra (nanomolar).
* ALGEBRAIC[8] is v2 in component v2 (flux).
* STATES[3] is R2 in component R2 (nanomolar).
* ALGEBRAIC[9] is v3 in component v3 (flux).
* ALGEBRAIC[10] is v4 in component v4 (flux).
* STATES[4] is RP in component RP (nanomolar).
* ALGEBRAIC[13] is v7 in component v7 (flux).
* ALGEBRAIC[18] is v11 in component v11 (flux).
* ALGEBRAIC[22] is v15 in component v15 (flux).
* ALGEBRAIC[25] is v18 in component v18 (flux).
* ALGEBRAIC[27] is v20 in component v20 (flux).
* ALGEBRAIC[11] is v5 in component v5 (flux).
* ALGEBRAIC[14] is v9 in component v9 (flux).
* ALGEBRAIC[20] is v13 in component v13 (flux).
* STATES[5] is R_PL in component R_PL (nanomolar).
* ALGEBRAIC[12] is v6 in component v6 (flux).
* STATES[6] is R_PLP in component R_PLP (nanomolar).
* STATES[7] is R_G in component R_G (nanomolar).
* ALGEBRAIC[16] is v10 in component v10 (flux).
* STATES[8] is R_G_S in component R_G_S (nanomolar).
* STATES[9] is R_Sh in component R_Sh (nanomolar).
* ALGEBRAIC[21] is v14 in component v14 (flux).
* STATES[10] is R_ShP in component R_ShP (nanomolar).
* ALGEBRAIC[31] is v24 in component v24 (flux).
* ALGEBRAIC[24] is v17 in component v17 (flux).
* STATES[11] is R_Sh_G in component R_Sh_G (nanomolar).
* ALGEBRAIC[26] is v19 in component v19 (flux).
* STATES[12] is R_Sh_G_S in component R_Sh_G_S (nanomolar).
* STATES[13] is G_S in component G_S (nanomolar).
* ALGEBRAIC[30] is v23 in component v23 (flux).
* ALGEBRAIC[19] is v12 in component v12 (flux).
* STATES[14] is ShP in component ShP (nanomolar).
* ALGEBRAIC[28] is v21 in component v21 (flux).
* ALGEBRAIC[23] is v16 in component v16 (flux).
* STATES[15] is Sh_G in component Sh_G (nanomolar).
* ALGEBRAIC[29] is v22 in component v22 (flux).
* STATES[16] is Sh_G_S in component Sh_G_S (nanomolar).
* STATES[17] is PLC_gamma in component PLC_gamma (nanomolar).
* ALGEBRAIC[15] is v8 in component v8 (flux).
* STATES[18] is PLC_gamma_P in component PLC_gamma_P (nanomolar).
* ALGEBRAIC[17] is v25 in component v25 (flux).
* STATES[19] is PLC_gamma_P_I in component PLC_gamma_P_I (nanomolar).
* STATES[20] is Grb in component Grb (nanomolar).
* STATES[21] is Shc in component Shc (nanomolar).
* STATES[22] is SOS in component SOS (nanomolar).
* CONSTANTS[0] is k1 in component v1 (second_order_rate_constant).
* CONSTANTS[1] is k1_ in component v1 (first_order_rate_constant).
* CONSTANTS[2] is k2 in component v2 (second_order_rate_constant).
* CONSTANTS[3] is k2_ in component v2 (first_order_rate_constant).
* CONSTANTS[4] is k3 in component v3 (first_order_rate_constant).
* CONSTANTS[5] is k3_ in component v3 (first_order_rate_constant).
* CONSTANTS[6] is K4 in component v4 (nanomolar).
* CONSTANTS[7] is V4 in component v4 (flux).
* CONSTANTS[8] is k5 in component v5 (second_order_rate_constant).
* CONSTANTS[9] is k5_ in component v5 (first_order_rate_constant).
* CONSTANTS[10] is k6 in component v6 (first_order_rate_constant).
* CONSTANTS[11] is k6_ in component v6 (first_order_rate_constant).
* CONSTANTS[12] is k7 in component v7 (first_order_rate_constant).
* CONSTANTS[13] is k7_ in component v7 (second_order_rate_constant).
* CONSTANTS[14] is K8 in component v8 (nanomolar).
* CONSTANTS[15] is V8 in component v8 (flux).
* CONSTANTS[16] is k9 in component v9 (second_order_rate_constant).
* CONSTANTS[17] is k9_ in component v9 (first_order_rate_constant).
* CONSTANTS[18] is k10 in component v10 (second_order_rate_constant).
* CONSTANTS[19] is k10_ in component v10 (first_order_rate_constant).
* CONSTANTS[20] is k11 in component v11 (first_order_rate_constant).
* CONSTANTS[21] is k11_ in component v11 (second_order_rate_constant).
* CONSTANTS[22] is k12 in component v12 (first_order_rate_constant).
* CONSTANTS[23] is k12_ in component v12 (second_order_rate_constant).
* CONSTANTS[24] is k13 in component v13 (second_order_rate_constant).
* CONSTANTS[25] is k13_ in component v13 (first_order_rate_constant).
* CONSTANTS[26] is k14 in component v14 (first_order_rate_constant).
* CONSTANTS[27] is k14_ in component v14 (first_order_rate_constant).
* CONSTANTS[28] is k15 in component v15 (first_order_rate_constant).
* CONSTANTS[29] is k15_ in component v15 (second_order_rate_constant).
* CONSTANTS[30] is K16 in component v16 (nanomolar).
* CONSTANTS[31] is V16 in component v16 (flux).
* CONSTANTS[32] is k17 in component v17 (second_order_rate_constant).
* CONSTANTS[33] is k17_ in component v17 (first_order_rate_constant).
* CONSTANTS[34] is k18 in component v18 (first_order_rate_constant).
* CONSTANTS[35] is k18_ in component v18 (second_order_rate_constant).
* CONSTANTS[36] is k19 in component v19 (second_order_rate_constant).
* CONSTANTS[37] is k19_ in component v19 (first_order_rate_constant).
* CONSTANTS[38] is k20 in component v20 (first_order_rate_constant).
* CONSTANTS[39] is k20_ in component v20 (second_order_rate_constant).
* CONSTANTS[40] is k21 in component v21 (second_order_rate_constant).
* CONSTANTS[41] is k21_ in component v21 (first_order_rate_constant).
* CONSTANTS[42] is k22 in component v22 (second_order_rate_constant).
* CONSTANTS[43] is k22_ in component v22 (first_order_rate_constant).
* CONSTANTS[44] is k23 in component v23 (first_order_rate_constant).
* CONSTANTS[45] is k23_ in component v23 (second_order_rate_constant).
* CONSTANTS[46] is k24 in component v24 (second_order_rate_constant).
* CONSTANTS[47] is k24_ in component v24 (first_order_rate_constant).
* CONSTANTS[48] is k25 in component v25 (first_order_rate_constant).
* CONSTANTS[49] is k25_ in component v25 (first_order_rate_constant).
* ALGEBRAIC[1] is totEGFRphos in component combined_concs (nanomolar).
* ALGEBRAIC[2] is totPLCgammaphos in component combined_concs (nanomolar).
* ALGEBRAIC[3] is totGrb_EGFR in component combined_concs (nanomolar).
* ALGEBRAIC[4] is totGrb_Shc in component combined_concs (nanomolar).
* ALGEBRAIC[5] is totShcphos in component combined_concs (nanomolar).
* ALGEBRAIC[6] is totShc_EGFR in component combined_concs (nanomolar).
* ALGEBRAIC[7] is totSOS_EGFR in component combined_concs (nanomolar).
* RATES[0] is d/dt EGF in component EGF (nanomolar).
* RATES[1] is d/dt R in component R (nanomolar).
* RATES[2] is d/dt Ra in component Ra (nanomolar).
* RATES[3] is d/dt R2 in component R2 (nanomolar).
* RATES[4] is d/dt RP in component RP (nanomolar).
* RATES[5] is d/dt R_PL in component R_PL (nanomolar).
* RATES[6] is d/dt R_PLP in component R_PLP (nanomolar).
* RATES[7] is d/dt R_G in component R_G (nanomolar).
* RATES[8] is d/dt R_G_S in component R_G_S (nanomolar).
* RATES[9] is d/dt R_Sh in component R_Sh (nanomolar).
* RATES[10] is d/dt R_ShP in component R_ShP (nanomolar).
* RATES[11] is d/dt R_Sh_G in component R_Sh_G (nanomolar).
* RATES[12] is d/dt R_Sh_G_S in component R_Sh_G_S (nanomolar).
* RATES[13] is d/dt G_S in component G_S (nanomolar).
* RATES[14] is d/dt ShP in component ShP (nanomolar).
* RATES[15] is d/dt Sh_G in component Sh_G (nanomolar).
* RATES[16] is d/dt Sh_G_S in component Sh_G_S (nanomolar).
* RATES[17] is d/dt PLC_gamma in component PLC_gamma (nanomolar).
* RATES[18] is d/dt PLC_gamma_P in component PLC_gamma_P (nanomolar).
* RATES[19] is d/dt PLC_gamma_P_I in component PLC_gamma_P_I (nanomolar).
* RATES[20] is d/dt Grb in component Grb (nanomolar).
* RATES[21] is d/dt Shc in component Shc (nanomolar).
* RATES[22] is d/dt SOS in component SOS (nanomolar).
*/
void
initConsts(double* CONSTANTS, double* RATES, double *STATES)
{
STATES[0] = 680;
STATES[1] = 100;
STATES[2] = 0;
STATES[3] = 0;
STATES[4] = 0;
STATES[5] = 0;
STATES[6] = 0;
STATES[7] = 0;
STATES[8] = 0;
STATES[9] = 0;
STATES[10] = 0;
STATES[11] = 0;
STATES[12] = 0;
STATES[13] = 0;
STATES[14] = 0;
STATES[15] = 0;
STATES[16] = 0;
STATES[17] = 105;
STATES[18] = 0;
STATES[19] = 0;
STATES[20] = 85;
STATES[21] = 150;
STATES[22] = 34;
CONSTANTS[0] = 0.003;
CONSTANTS[1] = 0.06;
CONSTANTS[2] = 0.01;
CONSTANTS[3] = 0.1;
CONSTANTS[4] = 1;
CONSTANTS[5] = 0.01;
CONSTANTS[6] = 50;
CONSTANTS[7] = 450;
CONSTANTS[8] = 0.06;
CONSTANTS[9] = 0.2;
CONSTANTS[10] = 1;
CONSTANTS[11] = 0.05;
CONSTANTS[12] = 0.3;
CONSTANTS[13] = 0.006;
CONSTANTS[14] = 100;
CONSTANTS[15] = 1;
CONSTANTS[16] = 0.003;
CONSTANTS[17] = 0.05;
CONSTANTS[18] = 0.01;
CONSTANTS[19] = 0.06;
CONSTANTS[20] = 0.03;
CONSTANTS[21] = 4.5e-3;
CONSTANTS[22] = 1.5e-3;
CONSTANTS[23] = 1e-4;
CONSTANTS[24] = 0.09;
CONSTANTS[25] = 0.6;
CONSTANTS[26] = 6;
CONSTANTS[27] = 0.06;
CONSTANTS[28] = 0.3;
CONSTANTS[29] = 9e-4;
CONSTANTS[30] = 340;
CONSTANTS[31] = 1.7;
CONSTANTS[32] = 0.003;
CONSTANTS[33] = 0.1;
CONSTANTS[34] = 0.3;
CONSTANTS[35] = 9e-4;
CONSTANTS[36] = 0.01;
CONSTANTS[37] = 2.14e-2;
CONSTANTS[38] = 0.12;
CONSTANTS[39] = 2.4e-4;
CONSTANTS[40] = 0.003;
CONSTANTS[41] = 0.1;
CONSTANTS[42] = 0.03;
CONSTANTS[43] = 0.064;
CONSTANTS[44] = 0.1;
CONSTANTS[45] = 0.021;
CONSTANTS[46] = 0.009;
CONSTANTS[47] = 4.29e-2;
CONSTANTS[48] = 1;
CONSTANTS[49] = 0.03;
}
void
computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[0] = CONSTANTS[0]*STATES[1]*STATES[0] - CONSTANTS[1]*STATES[2];
RATES[0] = - ALGEBRAIC[0];
RATES[1] = - ALGEBRAIC[0];
ALGEBRAIC[8] = CONSTANTS[2]*STATES[2]*STATES[2] - CONSTANTS[3]*STATES[3];
RATES[2] = ALGEBRAIC[0] - 2.00000*ALGEBRAIC[8];
ALGEBRAIC[9] = CONSTANTS[4]*STATES[3] - CONSTANTS[5]*STATES[4];
ALGEBRAIC[10] = ( CONSTANTS[7]*STATES[4])/(CONSTANTS[6]+STATES[4]);
RATES[3] = (ALGEBRAIC[8]+ALGEBRAIC[10]) - ALGEBRAIC[9];
ALGEBRAIC[11] = CONSTANTS[8]*STATES[4]*STATES[17] - CONSTANTS[9]*STATES[5];
ALGEBRAIC[12] = CONSTANTS[10]*STATES[5] - CONSTANTS[11]*STATES[6];
RATES[5] = ALGEBRAIC[11] - ALGEBRAIC[12];
ALGEBRAIC[13] = CONSTANTS[12]*STATES[6] - CONSTANTS[13]*STATES[4]*STATES[18];
RATES[6] = ALGEBRAIC[12] - ALGEBRAIC[13];
ALGEBRAIC[15] = ( CONSTANTS[15]*STATES[18])/(CONSTANTS[14]+STATES[18]);
RATES[17] = ALGEBRAIC[15] - ALGEBRAIC[11];
ALGEBRAIC[14] = CONSTANTS[16]*STATES[4]*STATES[20] - CONSTANTS[17]*STATES[7];
ALGEBRAIC[16] = CONSTANTS[18]*STATES[7]*STATES[22] - CONSTANTS[19]*STATES[8];
RATES[7] = ALGEBRAIC[14] - ALGEBRAIC[16];
ALGEBRAIC[17] = CONSTANTS[48]*STATES[18] - CONSTANTS[49]*STATES[19];
RATES[18] = ALGEBRAIC[13] - (ALGEBRAIC[15]+ALGEBRAIC[17]);
RATES[19] = ALGEBRAIC[17];
ALGEBRAIC[18] = CONSTANTS[20]*STATES[8] - CONSTANTS[21]*STATES[4]*STATES[13];
RATES[8] = ALGEBRAIC[16] - ALGEBRAIC[18];
ALGEBRAIC[20] = CONSTANTS[24]*STATES[4]*STATES[21] - CONSTANTS[25]*STATES[9];
ALGEBRAIC[21] = CONSTANTS[26]*STATES[9] - CONSTANTS[27]*STATES[10];
RATES[9] = ALGEBRAIC[20] - ALGEBRAIC[21];
ALGEBRAIC[23] = ( CONSTANTS[31]*STATES[14])/(CONSTANTS[30]+STATES[14]);
RATES[21] = ALGEBRAIC[23] - ALGEBRAIC[20];
ALGEBRAIC[25] = CONSTANTS[34]*STATES[11] - CONSTANTS[35]*STATES[4]*STATES[15];
ALGEBRAIC[24] = CONSTANTS[32]*STATES[10]*STATES[20] - CONSTANTS[33]*STATES[11];
ALGEBRAIC[26] = CONSTANTS[36]*STATES[11]*STATES[22] - CONSTANTS[37]*STATES[12];
RATES[11] = ALGEBRAIC[24] - (ALGEBRAIC[25]+ALGEBRAIC[26]);
ALGEBRAIC[22] = CONSTANTS[28]*STATES[10] - CONSTANTS[29]*STATES[14]*STATES[4];
ALGEBRAIC[27] = CONSTANTS[38]*STATES[12] - CONSTANTS[39]*STATES[16]*STATES[4];
RATES[4] = (ALGEBRAIC[9]+ALGEBRAIC[13]+ALGEBRAIC[18]+ALGEBRAIC[22]+ALGEBRAIC[25]+ALGEBRAIC[27]) - (ALGEBRAIC[10]+ALGEBRAIC[11]+ALGEBRAIC[14]+ALGEBRAIC[20]);
ALGEBRAIC[19] = CONSTANTS[22]*STATES[13] - CONSTANTS[23]*STATES[20]*STATES[22];
ALGEBRAIC[28] = CONSTANTS[40]*STATES[14]*STATES[20] - CONSTANTS[41]*STATES[15];
RATES[20] = ALGEBRAIC[19] - (ALGEBRAIC[14]+ALGEBRAIC[24]+ALGEBRAIC[28]);
ALGEBRAIC[29] = CONSTANTS[42]*STATES[15]*STATES[22] - CONSTANTS[43]*STATES[16];
RATES[15] = (ALGEBRAIC[25]+ALGEBRAIC[28]) - ALGEBRAIC[29];
RATES[22] = ALGEBRAIC[19] - (ALGEBRAIC[16]+ALGEBRAIC[26]+ALGEBRAIC[29]);
ALGEBRAIC[30] = CONSTANTS[44]*STATES[16] - CONSTANTS[45]*STATES[14]*STATES[13];
RATES[14] = (ALGEBRAIC[22]+ALGEBRAIC[30]) - (ALGEBRAIC[28]+ALGEBRAIC[23]);
RATES[16] = (ALGEBRAIC[27]+ALGEBRAIC[29]) - ALGEBRAIC[30];
ALGEBRAIC[31] = CONSTANTS[46]*STATES[10]*STATES[13] - CONSTANTS[47]*STATES[12];
RATES[10] = ALGEBRAIC[21] - (ALGEBRAIC[31]+ALGEBRAIC[22]+ALGEBRAIC[24]);
RATES[12] = (ALGEBRAIC[26]+ALGEBRAIC[31]) - ALGEBRAIC[27];
RATES[13] = (ALGEBRAIC[18]+ALGEBRAIC[30]) - (ALGEBRAIC[19]+ALGEBRAIC[31]);
}
void
computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[0] = CONSTANTS[0]*STATES[1]*STATES[0] - CONSTANTS[1]*STATES[2];
ALGEBRAIC[8] = CONSTANTS[2]*STATES[2]*STATES[2] - CONSTANTS[3]*STATES[3];
ALGEBRAIC[9] = CONSTANTS[4]*STATES[3] - CONSTANTS[5]*STATES[4];
ALGEBRAIC[10] = ( CONSTANTS[7]*STATES[4])/(CONSTANTS[6]+STATES[4]);
ALGEBRAIC[11] = CONSTANTS[8]*STATES[4]*STATES[17] - CONSTANTS[9]*STATES[5];
ALGEBRAIC[12] = CONSTANTS[10]*STATES[5] - CONSTANTS[11]*STATES[6];
ALGEBRAIC[13] = CONSTANTS[12]*STATES[6] - CONSTANTS[13]*STATES[4]*STATES[18];
ALGEBRAIC[15] = ( CONSTANTS[15]*STATES[18])/(CONSTANTS[14]+STATES[18]);
ALGEBRAIC[14] = CONSTANTS[16]*STATES[4]*STATES[20] - CONSTANTS[17]*STATES[7];
ALGEBRAIC[16] = CONSTANTS[18]*STATES[7]*STATES[22] - CONSTANTS[19]*STATES[8];
ALGEBRAIC[17] = CONSTANTS[48]*STATES[18] - CONSTANTS[49]*STATES[19];
ALGEBRAIC[18] = CONSTANTS[20]*STATES[8] - CONSTANTS[21]*STATES[4]*STATES[13];
ALGEBRAIC[20] = CONSTANTS[24]*STATES[4]*STATES[21] - CONSTANTS[25]*STATES[9];
ALGEBRAIC[21] = CONSTANTS[26]*STATES[9] - CONSTANTS[27]*STATES[10];
ALGEBRAIC[23] = ( CONSTANTS[31]*STATES[14])/(CONSTANTS[30]+STATES[14]);
ALGEBRAIC[25] = CONSTANTS[34]*STATES[11] - CONSTANTS[35]*STATES[4]*STATES[15];
ALGEBRAIC[24] = CONSTANTS[32]*STATES[10]*STATES[20] - CONSTANTS[33]*STATES[11];
ALGEBRAIC[26] = CONSTANTS[36]*STATES[11]*STATES[22] - CONSTANTS[37]*STATES[12];
ALGEBRAIC[22] = CONSTANTS[28]*STATES[10] - CONSTANTS[29]*STATES[14]*STATES[4];
ALGEBRAIC[27] = CONSTANTS[38]*STATES[12] - CONSTANTS[39]*STATES[16]*STATES[4];
ALGEBRAIC[19] = CONSTANTS[22]*STATES[13] - CONSTANTS[23]*STATES[20]*STATES[22];
ALGEBRAIC[28] = CONSTANTS[40]*STATES[14]*STATES[20] - CONSTANTS[41]*STATES[15];
ALGEBRAIC[29] = CONSTANTS[42]*STATES[15]*STATES[22] - CONSTANTS[43]*STATES[16];
ALGEBRAIC[30] = CONSTANTS[44]*STATES[16] - CONSTANTS[45]*STATES[14]*STATES[13];
ALGEBRAIC[31] = CONSTANTS[46]*STATES[10]*STATES[13] - CONSTANTS[47]*STATES[12];
ALGEBRAIC[1] = 2.00000*(STATES[4]+STATES[5]+STATES[6]+STATES[7]+STATES[8]+STATES[9]+STATES[10]+STATES[11]+STATES[12]);
ALGEBRAIC[2] = STATES[6]+STATES[18];
ALGEBRAIC[3] = STATES[7]+STATES[8]+STATES[11]+STATES[12];
ALGEBRAIC[4] = STATES[11]+STATES[15]+STATES[12]+STATES[16];
ALGEBRAIC[5] = STATES[10]+STATES[11]+STATES[12]+STATES[14]+STATES[15]+STATES[16];
ALGEBRAIC[6] = STATES[10]+STATES[11]+STATES[12];
ALGEBRAIC[7] = STATES[8]+STATES[12];
}