Model Mathematics

Component: environment

Component: EGF

ddtimeEGF=-v1

Component: R

ddtimeR=-v1

Component: Ra

ddtimeRa=v1-2v2

Component: R2

ddtimeR2=v2+v4-v3

Component: RP

ddtimeRP=v3+v7+v11+v15+v18+v20-v4+v5+v9+v13

Component: R_PL

ddtimeR_PL=v5-v6

Component: R_PLP

ddtimeR_PLP=v6-v7

Component: R_G

ddtimeR_G=v9-v10

Component: R_G_S

ddtimeR_G_S=v10-v11

Component: R_Sh

ddtimeR_Sh=v13-v14

Component: R_ShP

ddtimeR_ShP=v14-v24+v15+v17

Component: R_Sh_G

ddtimeR_Sh_G=v17-v18+v19

Component: R_Sh_G_S

ddtimeR_Sh_G_S=v19+v24-v20

Component: G_S

ddtimeG_S=v11+v23-v12+v24

Component: ShP

ddtimeShP=v15+v23-v21+v16

Component: Sh_G

ddtimeSh_G=v18+v21-v22

Component: Sh_G_S

ddtimeSh_G_S=v20+v22-v23

Component: PLC_gamma

ddtimePLC_gamma=v8-v5

Component: PLC_gamma_P

ddtimePLC_gamma_P=v7-v8+v25

Component: PLC_gamma_P_I

ddtimePLC_gamma_P_I=v25

Component: Grb

ddtimeGrb=v12-v9+v17+v21

Component: Shc

ddtimeShc=v16-v13

Component: SOS

ddtimeSOS=v12-v10+v19+v22

Component: v1

v1=k1REGF-k1_Ra

Component: v2

v2=k2RaRa-k2_R2

Component: v3

v3=k3R2-k3_RP

Component: v4

v4=V4RPK4+RP

Component: v5

v5=k5RPPLC_gamma-k5_R_PL

Component: v6

v6=k6R_PL-k6_R_PLP

Component: v7

v7=k7R_PLP-k7_RPPLC_gamma_P

Component: v8

v8=V8PLC_gamma_PK8+PLC_gamma_P

Component: v9

v9=k9RPGrb-k9_R_G

Component: v10

v10=k10R_GSOS-k10_R_G_S

Component: v11

v11=k11R_G_S-k11_RPG_S

Component: v12

v12=k12G_S-k12_GrbSOS

Component: v13

v13=k13RPShc-k13_R_Sh

Component: v14

v14=k14R_Sh-k14_R_ShP

Component: v15

v15=k15R_ShP-k15_ShPRP

Component: v16

v16=V16ShPK16+ShP

Component: v17

v17=k17R_ShPGrb-k17_R_Sh_G

Component: v18

v18=k18R_Sh_G-k18_RPSh_G

Component: v19

v19=k19R_Sh_GSOS-k19_R_Sh_G_S

Component: v20

v20=k20R_Sh_G_S-k20_Sh_G_SRP

Component: v21

v21=k21ShPGrb-k21_Sh_G

Component: v22

v22=k22Sh_GSOS-k22_Sh_G_S

Component: v23

v23=k23Sh_G_S-k23_ShPG_S

Component: v24

v24=k24R_ShPG_S-k24_R_Sh_G_S

Component: v25

v25=k25PLC_gamma_P-k25_PLC_gamma_P_I

Component: combined_concs

totEGFRphos=2RP+R_PL+R_PLP+R_G+R_G_S+R_Sh+R_ShP+R_Sh_G+R_Sh_G_S totPLCgammaphos=R_PLP+PLC_gamma_P totShcphos=R_ShP+R_Sh_G+R_Sh_G_S+ShP+Sh_G+Sh_G_S totGrb_EGFR=R_G+R_G_S+R_Sh_G+R_Sh_G_S totGrb_Shc=R_Sh_G+Sh_G+R_Sh_G_S+Sh_G_S totShc_EGFR=R_ShP+R_Sh_G+R_Sh_G_S totSOS_EGFR=R_G_S+R_Sh_G_S