Rendering of the source text

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This CellML file was generated on 20/06/2007 at 12:39:18 at a.m. using:

COR (0.9.31.649)
Copyright 2002-2007 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
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<article>
  <articleinfo>
  <title>Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: insights from a computational model</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
        This version of the model has been checked in COR and PCEnv and it runs - possibly replicating the published results.  The units have been checked and they are consistent.
    </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
The formation of new biological vessels requires the coordinated assembly of a proliferating syncytium of endothelial cells (EC) at different developmental stages.  Angiogenesis may also be an essential mechanism of blood vessel remodelling which occurs during a diverse range of physiological processes; including tissue regeneration following injury and new vessel formation during muscle exercise.  It can also occur under pathological conditions such as atherosclerosis and the vascularisation of cancerous tumours.
</para>

<para>
Matrix metalloproteinases (MMPs) are a family of enzymes responsible for the proteolytic processing of extracellular matrix (ECM) structural proteins.  During angiogenesis MMPs are expressed by a single endothelial cell at the tip of the new vessel.  These enzymes manifest a proteolytic activity that allows the cells of the new vessle to penetrate the ECM.  In the mathematical model presented here, Karagiannis and Popel investigate the proteolytic potential of such a tip endothelial cell.  The model authors suggest this model provides a foundation for future quantitative studies of angiogenesis in ECMs of different compositions.  The model is described in more detail in the figure below:
</para>

<para>
The complete original paper reference is cited below:
</para>

<para>
<ulink url="http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6WMD-4GJVBHT-2&amp;_user=140507&amp;_coverDate=01%2F07%2F2006&amp;_rdoc=12&amp;_fmt=summary&amp;_orig=browse&amp;_srch=doc-info(%23toc%236932%232006%23997619998%23612742%23FLA%23display%23Volume)&amp;_cdi=6932&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_ct=21&amp;_acct=C000011498&amp;_version=1&amp;_urlVersion=0&amp;_userid=140507&amp;md5=d5addc907496eab847175a55928184d0">Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: insights from a computational model</ulink>, Emmanouil D. Karagiannis and Aleksander S. Popel, 2006, <ulink url="http://www.elsevier.com/wps/find/journaldescription.cws_home/622904/description#description">
            <emphasis>The Journal of Theoretical Biology</emphasis>
          </ulink>, 238, 124-145. (<ulink url="http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6WMD-4GJVBHT-2&amp;_user=140507&amp;_coverDate=01%2F07%2F2006&amp;_rdoc=12&amp;_fmt=full&amp;_orig=browse&amp;_srch=doc-info(%23toc%236932%232006%23997619998%23612742%23FLA%23display%23Volume)&amp;_cdi=6932&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_ct=21&amp;_acct=C000011498&amp;_version=1&amp;_urlVersion=0&amp;_userid=140507&amp;md5=fc173e34bcf3e139ae316b2c34b309ef">Full text</ulink> and PDF versions of the article are available to subscribers on The Journal of Theoretical Biology website.)  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=16005020&amp;dopt=Abstract">PubMed ID: 16005020</ulink> 
</para>


<informalfigure float="0" id="fig_pathway_diagram">
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<caption>A schematic diagram of the signalling pathway.</caption>
</informalfigure>

</sect1>
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    <dc:title>The Journal of Theoretical Biology</dc:title>
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    <vCard:FN>Catherine Lloyd</vCard:FN>
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    <vCard:Given>Matthew</vCard:Given>
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        <rdf:li>signal transduction</rdf:li>
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    <dc:title>Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: insights from a computational model</dc:title>
    <bqs:volume>238</bqs:volume>
    <bqs:first_page>124</bqs:first_page>
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    <rdf:value>The model runs in PCEnv - but I'm not 100% sure whether or not it replicates the published results - these are displayed slightly differently.</rdf:value>
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    <vCard:Orgname>The University of Auckland</vCard:Orgname>
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    <vCard:Given>Aleksander</vCard:Given>
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    <vCard:Other>S</vCard:Other>
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    <dcterms:W3CDTF>2007-10-04T11:51:16+13:00</dcterms:W3CDTF>
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    <rdf:value>I ran the model in COR and corrected the units definitions such that the units are now consistent.</rdf:value>
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    <vCard:Given>Emmanouil</vCard:Given>
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