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<!--
This CellML file was generated on 14/11/2007 at 19:16:31 using:
COR (0.9.31.813)
Copyright 2002-2007 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>A mathematical treatment of integrated Ca dynamics within the ventricular myocyte</title>
<author>
<firstname>Martin</firstname>
<surname>Fink</surname>
<affiliation>
<shortaffil>Oxford University</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This is the original version of this model, replete with the typographical errors contained in the publication. This model is not able to replicate the published output.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Cardiac myocyte excitation-contraction coupling (ECC) is a complex process involving an array of different systems and proteins. While it is possible to study each of these systems in isolation, it is more meaningful to analyse them together, and mathematical models can facilitate this process. There are many examples of published mathematical models, based on experimental data, which describe the behaviour of the cardiac myocyte. Such models include:
</para>
<itemizedlist>
<listitem>
<para>
McAllister <emphasis>et al.</emphasis>, 1975.</para>
</listitem>
<listitem>
<para>
Beeler and Reuter, 1977;</para>
</listitem>
<listitem>
<para>
DiFrancesco and Noble, 1985;</para>
</listitem>
<listitem>
<para>
Luo and Rudy II, 1994;</para>
</listitem>
<listitem>
<para>
Priebe and Beuckelmann, 1998;</para>
</listitem>
<listitem>
<para>
Jafri, Rice and Winslow, 1998;</para>
</listitem>
<listitem>
<para>
Winslow <emphasis>et al.</emphasis>, 1999;</para>
</listitem>
<listitem>
<para>
Pandit <emphasis>et al.</emphasis>, 2003;</para>
</listitem>
<listitem>
<para>
Shiferaw <emphasis>et al.</emphasis>, 2003; and</para>
</listitem>
<listitem>
<para>
Bondarenko <emphasis>et al.</emphasis>, 2004.</para>
</listitem>
</itemizedlist>
<para>
Since the publication of these models new experimental data has become available, and this has been incorporated into a new model of rabbit cardiac myocyte calcium and sodium homeostasis. In their model, described here in CellML, Shannon <emphasis>et al.</emphasis> include a subsarcolemmal compartment, together with junctional and bulk sarcolemmal compartments, physiologically realistic cytosolic calcium buffering parameter values, a reversible sarcoplasmic reticulum calcium pump, a sodium-calcium exchanger that is dependent on the concentration of intracellular sodium and is also regulated by calcium, and finally, a model of sarcoplasmic reticulum calcium release.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.biophysj.org/cgi/content/abstract/87/5/3351">A mathematical treatment of integrated Ca dynamics within the ventricular myocyte</ulink>, Thomas R. Shannon, Fei Wang, Jose Puglisi, Christopher Weber and Donald M. Bers, 2004, <ulink url="http://ajpheart.physiology.org/">
<emphasis>Biophysical Journal</emphasis>
</ulink>, 87, 3351-3371. (<ulink url="http://www.biophysj.org/cgi/content/full/87/5/3351">Full text (HTML)</ulink> and <ulink url="http://www.biophysj.org/cgi/reprint/87/5/3351">PDF</ulink> versions of the article are available to subscribers on the <emphasis>Biophysical Journal</emphasis> website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15347581&dopt=Abstract">PubMed ID: 15347581</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram</title>
</objectinfo>
<imagedata fileref="shannon_2004.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram of the cell model which highlights the calcium- and sodium-dependent components of the model in particular.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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<cn cellml:units="per_millisecond">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_h</ci>
<piecewise>
<piece>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millisecond">3.56</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.079</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_millisecond">3.1e5</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.35</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="millisecond">0.13</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10.66</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">11.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>tau_h</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>alpha_h</ci>
<ci>beta_h</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>h_infinity</ci>
<apply>
<divide/>
<ci>alpha_h</ci>
<apply>
<plus/>
<ci>alpha_h</ci>
<ci>beta_h</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>h_infinity</ci>
<ci>h</ci>
</apply>
<ci>tau_h</ci>
</apply>
</apply>
</math>
</component>
<component name="INa_j_gate">
<variable units="dimensionless" public_interface="out" name="j" initial_value="0.991822731369"/>
<variable units="per_millisecond" name="alpha_j"/>
<variable units="per_millisecond" name="beta_j"/>
<variable units="millisecond" name="tau_j"/>
<variable units="dimensionless" name="j_infinity"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_j</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millisecond">1.2714e5</cn>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.2444</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_millisecond">3.474e-5</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.04391</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">37.78</cn>
</apply>
</apply>
<cn cellml:units="millivolt">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.311</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">79.23</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="per_millisecond">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_j</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.1212</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.01052</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1378</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">40.14</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.3</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">2.535e-7</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">32</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>tau_j</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>alpha_j</ci>
<ci>beta_j</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>j_infinity</ci>
<apply>
<divide/>
<ci>alpha_j</ci>
<apply>
<plus/>
<ci>alpha_j</ci>
<ci>beta_j</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>j</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>j_infinity</ci>
<ci>j</ci>
</apply>
<ci>tau_j</ci>
</apply>
</apply>
</math>
</component>
<component name="INa_m_gate">
<variable units="dimensionless" public_interface="out" name="m" initial_value="0.001370685156"/>
<variable units="per_millisecond" name="alpha_m"/>
<variable units="per_millisecond" name="beta_m"/>
<variable units="millisecond" name="tau_m"/>
<variable units="dimensionless" name="m_infinity"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_m</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.32</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">47.13</cn>
</apply>
</apply>
<cn cellml:units="millivolt">1</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">47.13</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_m</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.08</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">11</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_m</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>alpha_m</ci>
<ci>beta_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>m_infinity</ci>
<apply>
<divide/>
<ci>alpha_m</ci>
<apply>
<plus/>
<ci>alpha_m</ci>
<ci>beta_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>m_infinity</ci>
<ci>m</ci>
</apply>
<ci>tau_m</ci>
</apply>
</apply>
</math>
</component>
<component name="INab">
<variable units="microA_per_microF" public_interface="out" name="i_Nab"/>
<variable units="microA_per_microF" public_interface="out" name="i_Nab_jct"/>
<variable units="microA_per_microF" public_interface="out" name="i_Nab_SL"/>
<variable units="milliS_per_microF" name="G_NaBk" initial_value="0.297e-3"/>
<variable units="dimensionless" name="Fx_NaBk_jct" initial_value="0.11"/>
<variable units="dimensionless" name="Fx_NaBk_SL" initial_value="0.89"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millivolt" public_interface="in" name="E_Na_jct"/>
<variable units="millivolt" public_interface="in" name="E_Na_SL"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Nab_jct</ci>
<apply>
<times/>
<ci>Fx_NaBk_jct</ci>
<ci>G_NaBk</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na_jct</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Nab_SL</ci>
<apply>
<times/>
<ci>Fx_NaBk_SL</ci>
<ci>G_NaBk</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na_SL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Nab</ci>
<apply>
<plus/>
<ci>i_Nab_jct</ci>
<ci>i_Nab_SL</ci>
</apply>
</apply>
</math>
</component>
<component name="INaK">
<variable units="microA_per_microF" public_interface="out" name="i_NaK"/>
<variable units="microA_per_microF" public_interface="out" name="i_NaK_jct"/>
<variable units="microA_per_microF" public_interface="out" name="i_NaK_SL"/>
<variable units="dimensionless" name="f_NaK"/>
<variable units="dimensionless" name="Q10_NaK" initial_value="1.63"/>
<variable units="dimensionless" name="Q_NaK"/>
<variable units="dimensionless" name="H_NaK" initial_value="4"/>
<variable units="dimensionless" name="Q10_Km_Nai" initial_value="1.49"/>
<variable units="dimensionless" name="Q_Km_Nai"/>
<variable units="millimolar" name="Km_Nai" initial_value="11"/>
<variable units="millimolar" name="Km_Ko" initial_value="1.5"/>
<variable units="microA_per_microF" name="I_NaK_max" initial_value="1.91"/>
<variable units="dimensionless" name="sigma"/>
<variable units="dimensionless" name="Fx_NaK_jct" initial_value="0.11"/>
<variable units="dimensionless" name="Fx_NaK_SL" initial_value="0.89"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="coulomb_per_mole" public_interface="in" name="F"/>
<variable units="millimolar" public_interface="in" name="Nai"/>
<variable units="millimolar" public_interface="in" name="Na_jct"/>
<variable units="millimolar" public_interface="in" name="Na_SL"/>
<variable units="millimolar" public_interface="in" name="Nao"/>
<variable units="millimolar" public_interface="in" name="Ko"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Q_NaK</ci>
<apply>
<power/>
<ci>Q10_NaK</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">310</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_Km_Nai</ci>
<apply>
<power/>
<ci>Q10_Km_Nai</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">310</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Nao</ci>
<cn cellml:units="millimolar">67.3</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<cn cellml:units="dimensionless">7</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>f_NaK</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaK_jct</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Fx_NaK_jct</ci>
<ci>Q_NaK</ci>
<ci>I_NaK_max</ci>
<ci>f_NaK</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci>Q_Km_Nai</ci>
<ci>Km_Nai</ci>
</apply>
<ci>Na_jct</ci>
</apply>
<ci>H_NaK</ci>
</apply>
</apply>
</apply>
<ci>Ko</ci>
</apply>
<apply>
<plus/>
<ci>Ko</ci>
<ci>Km_Ko</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaK_SL</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Fx_NaK_SL</ci>
<ci>Q_NaK</ci>
<ci>I_NaK_max</ci>
<ci>f_NaK</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci>Q_Km_Nai</ci>
<ci>Km_Nai</ci>
</apply>
<ci>Na_SL</ci>
</apply>
<ci>H_NaK</ci>
</apply>
</apply>
</apply>
<ci>Ko</ci>
</apply>
<apply>
<plus/>
<ci>Ko</ci>
<ci>Km_Ko</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<plus/>
<ci>i_NaK_jct</ci>
<ci>i_NaK_SL</ci>
</apply>
</apply>
</math>
</component>
<component name="IKr">
<variable units="microA_per_microF" public_interface="out" name="i_Kr"/>
<variable units="milliS_per_microF" name="G_IKr"/>
<variable units="millisecond" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="millimolar" public_interface="in" name="Ko"/>
<variable units="dimensionless" private_interface="in" name="Xr"/>
<variable units="dimensionless" private_interface="in" name="Rr"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>G_IKr</ci>
<apply>
<times/>
<cn cellml:units="milliS_per_microF">0.03</cn>
<apply>
<root/>
<apply>
<divide/>
<ci>Ko</ci>
<cn cellml:units="millimolar">5.4</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Kr</ci>
<apply>
<times/>
<ci>G_IKr</ci>
<ci>Xr</ci>
<ci>Rr</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="IKr_Xr_gate">
<variable units="dimensionless" public_interface="out" name="Xr" initial_value="0.008471550841"/>
<variable units="dimensionless" name="Xr_infinity"/>
<variable units="millisecond" name="tau_Xr"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Xr</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Xr_infinity</ci>
<ci>Xr</ci>
</apply>
<ci>tau_Xr</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Xr_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<cn cellml:units="millivolt">50</cn>
<ci>V</ci>
</apply>
</apply>
<cn cellml:units="millivolt">7.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_Xr</ci>
<apply>
<divide/>
<cn cellml:units="millisecond">1</cn>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.00138</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">7</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.123</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.00061</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.145</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="IKr_Rr_gate">
<variable units="dimensionless" public_interface="out" name="Rr"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Rr</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<cn cellml:units="millivolt">33</cn>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">22.4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="IKs">
<variable units="microA_per_microF" public_interface="out" name="i_Ks"/>
<variable units="microA_per_microF" name="i_Ks_jct"/>
<variable units="microA_per_microF" name="i_Ks_SL"/>
<variable units="milliS_per_microF" name="G_Ks_SL"/>
<variable units="milliS_per_microF" name="G_Ks_jct"/>
<variable units="dimensionless" name="Fx_Ks_jct" initial_value="0.11"/>
<variable units="dimensionless" name="Fx_Ks_SL" initial_value="0.89"/>
<variable units="millivolt" name="E_Ks_jct"/>
<variable units="millivolt" name="E_Ks_SL"/>
<variable units="millivolt" name="E_Ks"/>
<variable units="dimensionless" name="pKNa" initial_value="0.01833"/>
<variable units="dimensionless" name="pCa_jct"/>
<variable units="dimensionless" name="pCa_SL"/>
<variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="coulomb_per_mole" public_interface="in" name="F"/>
<variable units="millimolar" public_interface="in" name="Nai"/>
<variable units="millimolar" public_interface="in" name="Na_jct"/>
<variable units="millimolar" public_interface="in" name="Na_SL"/>
<variable units="millimolar" public_interface="in" name="Nao"/>
<variable units="millimolar" public_interface="in" name="Ki"/>
<variable units="millimolar" public_interface="in" name="Ca_jct"/>
<variable units="millimolar" public_interface="in" name="Ca_SL"/>
<variable units="millimolar" public_interface="in" name="Ko"/>
<variable units="millisecond" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="dimensionless" private_interface="in" name="Xs"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>pCa_jct</ci>
<apply>
<minus/>
<apply>
<log/>
<apply>
<plus/>
<apply>
<divide/>
<ci>Ca_jct</ci>
<cn cellml:units="millimolar">1</cn>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pCa_SL</ci>
<apply>
<minus/>
<apply>
<log/>
<apply>
<plus/>
<apply>
<divide/>
<ci>Ca_SL</ci>
<cn cellml:units="millimolar">1</cn>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>G_Ks_jct</ci>
<apply>
<times/>
<cn cellml:units="milliS_per_microF">0.07</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.057</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.19</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">7.2</cn>
</apply>
<apply>
<divide/>
<ci>pCa_jct</ci>
<cn cellml:units="dimensionless">0.6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>G_Ks_SL</ci>
<apply>
<times/>
<cn cellml:units="milliS_per_microF">0.07</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.057</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.19</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">7.2</cn>
</apply>
<apply>
<divide/>
<ci>pCa_SL</ci>
<cn cellml:units="dimensionless">0.6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Ks_jct</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ko</ci>
<apply>
<times/>
<ci>pKNa</ci>
<ci>Nao</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>Ki</ci>
<apply>
<times/>
<ci>pKNa</ci>
<ci>Na_jct</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Ks_SL</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ko</ci>
<apply>
<times/>
<ci>pKNa</ci>
<ci>Nao</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>Ki</ci>
<apply>
<times/>
<ci>pKNa</ci>
<ci>Na_SL</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Ks</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ko</ci>
<apply>
<times/>
<ci>pKNa</ci>
<ci>Nao</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>Ki</ci>
<apply>
<times/>
<ci>pKNa</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ks_jct</ci>
<apply>
<times/>
<ci>Fx_Ks_jct</ci>
<ci>G_Ks_jct</ci>
<apply>
<power/>
<ci>Xs</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ks_SL</ci>
<apply>
<times/>
<ci>Fx_Ks_SL</ci>
<ci>G_Ks_SL</ci>
<apply>
<power/>
<ci>Xs</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ks</ci>
<apply>
<plus/>
<ci>i_Ks_jct</ci>
<ci>i_Ks_SL</ci>
</apply>
</apply>
</math>
</component>
<component name="IKs_Xs_gate">
<variable units="dimensionless" public_interface="out" name="Xs" initial_value="0.00687399199"/>
<variable units="dimensionless" name="Xs_infinity"/>
<variable units="millisecond" name="tau_Xs"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Xs</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Xs_infinity</ci>
<ci>Xs</ci>
</apply>
<ci>tau_Xs</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Xs_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">1.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">16.7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_Xs</ci>
<apply>
<divide/>
<cn cellml:units="millisecond">1</cn>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt">7.19e-5</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.148</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt">1.31e-4</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.0687</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Itos">
<variable units="microA_per_microF" public_interface="out" name="i_tos"/>
<variable units="milliS_per_microF" name="G_tos" initial_value="0.02"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="millisecond" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="dimensionless" private_interface="in" name="Y_tos"/>
<variable units="dimensionless" private_interface="in" name="X_tos"/>
<variable units="dimensionless" private_interface="in" name="R_tos"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_tos</ci>
<apply>
<times/>
<ci>G_tos</ci>
<ci>X_tos</ci>
<apply>
<plus/>
<ci>Y_tos</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>R_tos</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Itos_X_gate">
<variable units="dimensionless" public_interface="out" name="X_tos" initial_value="0.004011272375"/>
<variable units="dimensionless" name="X_tos_infinity"/>
<variable units="millisecond" name="tau_X_tos"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>X_tos</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>X_tos_infinity</ci>
<ci>X_tos</ci>
</apply>
<ci>tau_X_tos</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>X_tos_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">3</cn>
</apply>
</apply>
<cn cellml:units="millivolt">15</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_X_tos</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="millisecond">9</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">3</cn>
</apply>
<cn cellml:units="millivolt">15</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="millisecond">0.5</cn>
</apply>
</apply>
</math>
</component>
<component name="Itos_Y_gate">
<variable units="dimensionless" public_interface="out" name="Y_tos" initial_value="0.293519921626"/>
<variable units="dimensionless" name="Y_tos_infinity"/>
<variable units="millisecond" name="tau_Y_tos"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Y_tos</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Y_tos_infinity</ci>
<ci>Y_tos</ci>
</apply>
<ci>tau_Y_tos</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Y_tos_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">33.5</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_Y_tos</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="millisecond">3000</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">60</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="millisecond">30</cn>
</apply>
</apply>
</math>
</component>
<component name="Itos_R_gate">
<variable units="dimensionless" public_interface="out" name="R_tos_other" initial_value="0.383430556383"/>
<variable units="dimensionless" name="R_tos_infinity"/>
<variable units="dimensionless" public_interface="out" name="R_tos"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" name="tau_R_tos"/>
<variable units="millisecond" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>R_tos_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">33.5</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_R_tos</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="millisecond">2.8e3</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">60</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="millisecond">220</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>R_tos</ci>
<ci>R_tos_infinity</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>R_tos_other</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>R_tos_infinity</ci>
<ci>R_tos</ci>
</apply>
<ci>tau_R_tos</ci>
</apply>
</apply>
</math>
</component>
<component name="Itof">
<variable units="microA_per_microF" public_interface="out" name="i_tof"/>
<variable units="milliS_per_microF" name="G_tof" initial_value="0.06"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="millisecond" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="dimensionless" private_interface="in" name="Y_tof"/>
<variable units="dimensionless" private_interface="in" name="X_tof"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_tof</ci>
<apply>
<times/>
<ci>G_tof</ci>
<ci>X_tof</ci>
<ci>Y_tof</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Itof_X_gate">
<variable units="dimensionless" public_interface="out" name="X_tof" initial_value="0.00401120993"/>
<variable units="dimensionless" name="X_tof_infinity"/>
<variable units="millisecond" name="tau_X_tof"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>X_tof</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>X_tof_infinity</ci>
<ci>X_tof</ci>
</apply>
<ci>tau_X_tof</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>X_tof_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">3</cn>
</apply>
</apply>
<cn cellml:units="millivolt">15</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_X_tof</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="millisecond">3.5</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="millisecond">1.5</cn>
</apply>
</apply>
</math>
</component>
<component name="Itof_Y_gate">
<variable units="dimensionless" public_interface="out" name="Y_tof" initial_value="0.9946314893"/>
<variable units="dimensionless" name="Y_tof_infinity"/>
<variable units="millisecond" name="tau_Y_tof"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Y_tof</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Y_tof_infinity</ci>
<ci>Y_tof</ci>
</apply>
<ci>tau_Y_tof</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Y_tof_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">33.5</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_Y_tof</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="millisecond">20</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">33.5</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="millisecond">20</cn>
</apply>
</apply>
</math>
</component>
<component name="IK1">
<variable units="microA_per_microF" public_interface="out" name="i_K1"/>
<variable units="milliS_per_microF" name="G_K1"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="E_K"/>
<variable units="millimolar" public_interface="in" name="Ko"/>
<variable units="dimensionless" private_interface="in" name="K1_infinity"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>G_K1</ci>
<apply>
<times/>
<cn cellml:units="milliS_per_microF">0.9</cn>
<apply>
<root/>
<apply>
<divide/>
<ci>Ko</ci>
<cn cellml:units="millimolar">5.4</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<times/>
<ci>G_K1</ci>
<ci>K1_infinity</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="IK1_K1_gate">
<variable units="dimensionless" public_interface="out" name="K1_infinity"/>
<variable units="per_millisecond" name="alpha_K1"/>
<variable units="per_millisecond" name="beta_K1"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K1_infinity</ci>
<apply>
<divide/>
<ci>alpha_K1</ci>
<apply>
<plus/>
<ci>alpha_K1</ci>
<ci>beta_K1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_K1</ci>
<apply>
<divide/>
<cn cellml:units="per_millisecond">1.02</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.2385</cn>
<apply>
<minus/>
<ci>V</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn cellml:units="millivolt">59.215</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_K1</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.49124</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.08032</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<cn cellml:units="millivolt">5.476</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_millisecond">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.06175</cn>
<apply>
<minus/>
<ci>V</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn cellml:units="millivolt">594.31</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.5143</cn>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<cn cellml:units="millivolt">4.753</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="IKp">
<variable units="microA_per_microF" public_interface="out" name="i_Kp"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="milliS_per_microF" name="g_Kp" initial_value="0.001"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kp</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>g_Kp</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<cn cellml:units="dimensionless">7.488</cn>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="millivolt">5.98</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ICl_Ca">
<variable units="microA_per_microF" public_interface="out" name="i_Cl_Ca"/>
<variable units="milliS_per_microF" name="G_Cl" initial_value="0.109625"/>
<variable units="millimolar" name="Kd_ClCa" initial_value="0.1"/>
<variable units="dimensionless" name="Fx_Cl_jct" initial_value="0.11"/>
<variable units="dimensionless" name="Fx_Cl_SL" initial_value="0.89"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millivolt" public_interface="in" name="E_Cl"/>
<variable units="millimolar" public_interface="in" name="Ca_jct"/>
<variable units="millimolar" public_interface="in" name="Ca_SL"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Cl_Ca</ci>
<apply>
<times/>
<ci>G_Cl</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Cl</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<ci>Fx_Cl_jct</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Kd_ClCa</ci>
<ci>Ca_jct</ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci>Fx_Cl_SL</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Kd_ClCa</ci>
<ci>Ca_SL</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="IClb">
<variable units="microA_per_microF" public_interface="out" name="i_Clb"/>
<variable units="milliS_per_microF" name="G_ClBk" initial_value="0.009"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millivolt" public_interface="in" name="E_Cl"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Clb</ci>
<apply>
<times/>
<ci>G_ClBk</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Cl</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ICaL">
<variable units="microA_per_microF" public_interface="out" name="i_CaL"/>
<variable units="microA_per_microF" public_interface="out" name="i_CaL_Ca_SL"/>
<variable units="microA_per_microF" public_interface="out" name="i_CaL_Ca_jct"/>
<variable units="microA_per_microF" public_interface="out" name="i_CaL_Na_SL"/>
<variable units="microA_per_microF" public_interface="out" name="i_CaL_Na_jct"/>
<variable units="microA_per_microF" name="i_CaL_K"/>
<variable units="litre_per_farad_millisecond" name="PCa" initial_value="5.4e-4"/>
<variable units="litre_per_farad_millisecond" name="PNa" initial_value="1.5e-8"/>
<variable units="litre_per_farad_millisecond" name="PK" initial_value="2.7e-7"/>
<variable units="dimensionless" name="Fx_ICaL_jct" initial_value="0.9"/>
<variable units="dimensionless" name="Fx_ICaL_SL" initial_value="0.1"/>
<variable units="dimensionless" name="gamma_Cai" initial_value="0.341"/>
<variable units="dimensionless" name="gamma_Cao" initial_value="0.341"/>
<variable units="dimensionless" name="gamma_Nai" initial_value="0.75"/>
<variable units="dimensionless" name="gamma_Nao" initial_value="0.75"/>
<variable units="dimensionless" name="gamma_Ki" initial_value="0.75"/>
<variable units="dimensionless" name="gamma_Ko" initial_value="0.75"/>
<variable units="dimensionless" name="Q10_CaL" initial_value="1.8"/>
<variable units="dimensionless" name="Q_CaL"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="millisecond" public_interface="in" private_interface="out" name="time"/>
<variable units="millimolar" public_interface="in" private_interface="out" name="Cai"/>
<variable units="millimolar" public_interface="in" name="Na_SL"/>
<variable units="millimolar" public_interface="in" name="Na_jct"/>
<variable units="millimolar" public_interface="in" name="Nao"/>
<variable units="millimolar" public_interface="in" private_interface="out" name="Ca_SL"/>
<variable units="millimolar" public_interface="in" private_interface="out" name="Ca_jct"/>
<variable units="millimolar" public_interface="in" name="Cao"/>
<variable units="millimolar" public_interface="in" name="Ki"/>
<variable units="millimolar" public_interface="in" name="Ko"/>
<variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="coulomb_per_mole" public_interface="in" name="F"/>
<variable units="dimensionless" private_interface="in" name="d"/>
<variable units="dimensionless" private_interface="in" name="f"/>
<variable units="dimensionless" private_interface="in" name="fCa_SL"/>
<variable units="dimensionless" private_interface="in" name="fCa_jct"/>
<variable units="coulomb_per_mole" name="temp"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Q_CaL</ci>
<apply>
<power/>
<ci>Q10_CaL</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">310</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>temp</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>d</ci>
<ci>f</ci>
<ci>Q_CaL</ci>
<ci>V</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_Ca_jct</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>temp</ci>
<ci>fCa_jct</ci>
<ci>Fx_ICaL_jct</ci>
<ci>PCa</ci>
<cn cellml:units="dimensionless">4</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>gamma_Cai</ci>
<ci>Ca_jct</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>gamma_Cao</ci>
<ci>Cao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_Na_jct</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>temp</ci>
<ci>fCa_jct</ci>
<ci>Fx_ICaL_jct</ci>
<ci>PNa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>gamma_Nai</ci>
<ci>Na_jct</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>gamma_Nao</ci>
<ci>Nao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_Ca_SL</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>temp</ci>
<ci>fCa_SL</ci>
<ci>Fx_ICaL_SL</ci>
<ci>PCa</ci>
<cn cellml:units="dimensionless">4</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>gamma_Cai</ci>
<ci>Ca_SL</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>gamma_Cao</ci>
<ci>Cao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_Na_SL</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>temp</ci>
<ci>fCa_SL</ci>
<ci>Fx_ICaL_SL</ci>
<ci>PNa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>gamma_Nai</ci>
<ci>Na_SL</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>gamma_Nao</ci>
<ci>Nao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_K</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>temp</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>fCa_SL</ci>
<ci>Fx_ICaL_SL</ci>
</apply>
<apply>
<times/>
<ci>fCa_jct</ci>
<ci>Fx_ICaL_jct</ci>
</apply>
</apply>
<ci>PK</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>gamma_Ki</ci>
<ci>Ki</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>gamma_Ko</ci>
<ci>Ko</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL</ci>
<apply>
<plus/>
<ci>i_CaL_Ca_SL</ci>
<ci>i_CaL_Ca_jct</ci>
<ci>i_CaL_Na_SL</ci>
<ci>i_CaL_Na_jct</ci>
<ci>i_CaL_K</ci>
</apply>
</apply>
</math>
</component>
<component name="ICaL_d_gate">
<variable units="dimensionless" public_interface="out" name="d" initial_value="0.000006997531"/>
<variable units="dimensionless" name="d_infinity"/>
<variable units="millisecond" name="tau_d"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>d_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_d</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millisecond">1</cn>
<ci>d_infinity</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">6</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.035</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.5</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>d_infinity</ci>
<ci>d</ci>
</apply>
<ci>tau_d</ci>
</apply>
</apply>
</math>
</component>
<component name="ICaL_f_gate">
<variable units="dimensionless" public_interface="out" name="f" initial_value="1.000675515962"/>
<variable units="dimensionless" name="f_infinity"/>
<variable units="millisecond" name="tau_f"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_infinity</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">35.06</cn>
</apply>
<cn cellml:units="millivolt">3.6</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.6</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="millivolt">50</cn>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f</ci>
<apply>
<divide/>
<cn cellml:units="millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0197</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.0337</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.5</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">0.02</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_infinity</ci>
<ci>f</ci>
</apply>
<ci>tau_f</ci>
</apply>
</apply>
</math>
</component>
<component name="ICaL_fCa_gate">
<variable units="dimensionless" public_interface="out" name="fCa_SL"/>
<variable units="dimensionless" public_interface="out" name="fCa_jct"/>
<variable units="dimensionless" public_interface="out" name="fCaB_SL" initial_value="0.015352888928"/>
<variable units="dimensionless" public_interface="out" name="fCaB_jct" initial_value="0.024609183734"/>
<variable units="millimolar" public_interface="in" name="Ca_SL"/>
<variable units="millimolar" public_interface="in" name="Ca_jct"/>
<variable units="millisecond" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>fCa_SL</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fCaB_SL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>fCa_jct</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fCaB_jct</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCaB_SL</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="per_millimolar_millisecond">1.7</cn>
<ci>Ca_SL</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fCaB_SL</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_millisecond">11.9</cn>
<ci>fCaB_SL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCaB_jct</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="per_millimolar_millisecond">1.7</cn>
<ci>Ca_jct</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fCaB_jct</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_millisecond">11.9</cn>
<ci>fCaB_jct</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="INaCa">
<variable units="microA_per_microF" public_interface="out" name="i_NaCa"/>
<variable units="microA_per_microF" public_interface="out" name="i_NaCa_SL"/>
<variable units="microA_per_microF" public_interface="out" name="i_NaCa_jct"/>
<variable units="microA_per_microF" name="V_max" initial_value="9"/>
<variable units="dimensionless" name="Fx_NCX_jct" initial_value="0.11"/>
<variable units="dimensionless" name="Fx_NCX_SL" initial_value="0.89"/>
<variable units="dimensionless" name="Q10_NCX" initial_value="1.57"/>
<variable units="dimensionless" name="Q_NCX"/>
<variable units="millimolar" name="K_mNai" initial_value="12.29"/>
<variable units="millimolar" name="K_mCao" initial_value="1.3"/>
<variable units="millimolar" name="K_mNao" initial_value="87.5"/>
<variable units="millimolar" name="K_mCai" initial_value="0.00359"/>
<variable units="dimensionless" name="Ka_SL"/>
<variable units="dimensionless" name="Ka_jct"/>
<variable units="millimolar" name="Kd_act" initial_value="0.000256"/>
<variable units="dimensionless" name="ksat" initial_value="0.27"/>
<variable units="dimensionless" name="eta" initial_value="0.35"/>
<variable units="dimensionless" name="HNa" initial_value="3"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="coulomb_per_mole" public_interface="in" name="F"/>
<variable units="millimolar" public_interface="in" name="Nai"/>
<variable units="millimolar" public_interface="in" name="Na_SL"/>
<variable units="millimolar" public_interface="in" name="Na_jct"/>
<variable units="millimolar" public_interface="in" name="Nao"/>
<variable units="millimolar" public_interface="in" name="Cai"/>
<variable units="millimolar" public_interface="in" name="Ca_SL"/>
<variable units="millimolar" public_interface="in" name="Ca_jct"/>
<variable units="millimolar" public_interface="in" name="Cao"/>
<variable units="millimolar4" name="temp_jct"/>
<variable units="millimolar4" name="temp_SL"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>temp_jct</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>eta</ci>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_jct</ci>
<ci>HNa</ci>
</apply>
<ci>Cao</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<ci>HNa</ci>
</apply>
<ci>Ca_jct</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>ksat</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>temp_SL</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>eta</ci>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_SL</ci>
<ci>HNa</ci>
</apply>
<ci>Cao</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<ci>HNa</ci>
</apply>
<ci>Ca_SL</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>ksat</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_NCX</ci>
<apply>
<power/>
<ci>Q10_NCX</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">310</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ka_SL</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Kd_act</ci>
<ci>Ca_SL</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ka_jct</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Kd_act</ci>
<ci>Ca_jct</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaCa_jct</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Fx_NCX_jct</ci>
<ci>V_max</ci>
<ci>Ka_jct</ci>
<ci>Q_NCX</ci>
<ci>temp_jct</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>K_mCai</ci>
<apply>
<power/>
<ci>Nao</ci>
<ci>HNa</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Na_jct</ci>
<ci>K_mNai</ci>
</apply>
<ci>HNa</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>K_mNao</ci>
<ci>HNa</ci>
</apply>
<ci>Ca_jct</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_jct</ci>
<ci>K_mCai</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>K_mCao</ci>
<apply>
<power/>
<ci>Na_jct</ci>
<ci>HNa</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Na_jct</ci>
<ci>HNa</ci>
</apply>
<ci>Cao</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Nao</ci>
<ci>HNa</ci>
</apply>
<ci>Ca_jct</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaCa_SL</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Fx_NCX_SL</ci>
<ci>V_max</ci>
<ci>Ka_SL</ci>
<ci>Q_NCX</ci>
<ci>temp_SL</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>K_mCai</ci>
<apply>
<power/>
<ci>Nao</ci>
<ci>HNa</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Na_SL</ci>
<ci>K_mNai</ci>
</apply>
<ci>HNa</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>K_mNao</ci>
<ci>HNa</ci>
</apply>
<ci>Ca_SL</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_SL</ci>
<ci>K_mCai</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>K_mCao</ci>
<apply>
<power/>
<ci>Na_SL</ci>
<ci>HNa</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Na_SL</ci>
<ci>HNa</ci>
</apply>
<ci>Cao</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Nao</ci>
<ci>HNa</ci>
</apply>
<ci>Ca_SL</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<plus/>
<ci>i_NaCa_jct</ci>
<ci>i_NaCa_SL</ci>
</apply>
</apply>
</math>
</component>
<component name="ICap">
<variable units="microA_per_microF" public_interface="out" name="i_Cap"/>
<variable units="microA_per_microF" public_interface="out" name="i_Cap_SL"/>
<variable units="microA_per_microF" public_interface="out" name="i_Cap_jct"/>
<variable units="millimolar_per_millisecond" name="V_max" initial_value="2.2e-6"/>
<variable units="dimensionless" name="Fx_SLCaP_jct" initial_value="0.11"/>
<variable units="dimensionless" name="Fx_SLCaP_SL" initial_value="0.89"/>
<variable units="dimensionless" name="Q10_SLCaP" initial_value="2.35"/>
<variable units="dimensionless" name="Q_SLCaP"/>
<variable units="millimolar" name="Km" initial_value="0.0005"/>
<variable units="dimensionless" name="H" initial_value="1.6"/>
<variable units="millimolar" public_interface="in" name="Cai"/>
<variable units="millimolar" public_interface="in" name="Ca_SL"/>
<variable units="millimolar" public_interface="in" name="Ca_jct"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="coulomb_per_mole" public_interface="in" name="F"/>
<variable units="litre" public_interface="in" name="Vol_cytosol"/>
<variable units="farad" public_interface="in" name="Cm"/>
<variable units="microA_per_microF" name="V_maxAF_old"/>
<variable units="microA_per_microF" name="V_maxAF" initial_value="0.0673"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_maxAF_old</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_max</ci>
<ci>Vol_cytosol</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
<ci>Cm</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_SLCaP</ci>
<apply>
<power/>
<ci>Q10_SLCaP</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">310</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Cap_jct</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Q_SLCaP</ci>
<ci>V_maxAF</ci>
<ci>Fx_SLCaP_jct</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km</ci>
<ci>Ca_jct</ci>
</apply>
<ci>H</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Cap_SL</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Q_SLCaP</ci>
<ci>V_maxAF</ci>
<ci>Fx_SLCaP_SL</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km</ci>
<ci>Ca_SL</ci>
</apply>
<ci>H</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Cap</ci>
<apply>
<plus/>
<ci>i_Cap_jct</ci>
<ci>i_Cap_SL</ci>
</apply>
</apply>
</math>
</component>
<component name="ICab">
<variable units="microA_per_microF" public_interface="out" name="i_Cab"/>
<variable units="microA_per_microF" public_interface="out" name="i_Cab_jct"/>
<variable units="microA_per_microF" public_interface="out" name="i_Cab_SL"/>
<variable units="milliS_per_microF" name="G_CaBk" initial_value="0.0002513"/>
<variable units="dimensionless" name="Fx_CaBk_jct" initial_value="0.11"/>
<variable units="dimensionless" name="Fx_CaBk_SL" initial_value="0.89"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millivolt" public_interface="in" name="E_Ca_SL"/>
<variable units="millivolt" public_interface="in" name="E_Ca_jct"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Cab_jct</ci>
<apply>
<times/>
<ci>G_CaBk</ci>
<ci>Fx_CaBk_jct</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca_jct</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Cab_SL</ci>
<apply>
<times/>
<ci>G_CaBk</ci>
<ci>Fx_CaBk_SL</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca_SL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Cab</ci>
<apply>
<plus/>
<ci>i_Cab_SL</ci>
<ci>i_Cab_jct</ci>
</apply>
</apply>
</math>
</component>
<component name="Jrel_SR">
<variable units="millimolar_per_millisecond" public_interface="out" name="j_rel_SR"/>
<variable units="dimensionless" name="Max_SR" initial_value="15"/>
<variable units="dimensionless" name="Min_SR" initial_value="1"/>
<variable units="millimolar" name="EC50_SR" initial_value="0.45"/>
<variable units="dimensionless" public_interface="out" name="R" initial_value="0.884673513138"/>
<variable units="dimensionless" public_interface="out" name="I" initial_value="0.00000009272"/>
<variable units="dimensionless" name="RI"/>
<variable units="dimensionless" public_interface="out" name="O" initial_value="0.000000711264"/>
<variable units="per_millisecond" name="ks" initial_value="25"/>
<variable units="per_millimolar2_per_millisecond" name="koCa" initial_value="10"/>
<variable units="per_millisecond" name="kom" initial_value="0.06"/>
<variable units="per_millimolar_per_millisecond" name="kiCa" initial_value="0.5"/>
<variable units="per_millisecond" name="kim" initial_value="0.005"/>
<variable units="dimensionless" name="HSR" initial_value="2.5"/>
<variable units="millimolar" public_interface="in" name="Ca_jct"/>
<variable units="millimolar" public_interface="in" name="Ca_SR"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="dimensionless" name="kCaSR"/>
<variable units="per_millimolar2_per_millisecond" name="koSRCa"/>
<variable units="per_millimolar_per_millisecond" name="kiSRCa"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>kCaSR</ci>
<apply>
<minus/>
<ci>Max_SR</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Max_SR</ci>
<ci>Min_SR</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>EC50_SR</ci>
<ci>Ca_SR</ci>
</apply>
<ci>HSR</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>koSRCa</ci>
<apply>
<divide/>
<ci>koCa</ci>
<ci>kCaSR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>kiSRCa</ci>
<apply>
<times/>
<ci>kiCa</ci>
<ci>kCaSR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>RI</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>R</ci>
</apply>
<ci>O</ci>
</apply>
<ci>I</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>R</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>kim</ci>
<ci>RI</ci>
</apply>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_jct</ci>
<ci>R</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_jct</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>R</ci>
</apply>
<apply>
<times/>
<ci>kom</ci>
<ci>O</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_jct</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>R</ci>
</apply>
<apply>
<times/>
<ci>kom</ci>
<ci>O</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_jct</ci>
<ci>O</ci>
</apply>
<apply>
<times/>
<ci>kim</ci>
<ci>I</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>I</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_jct</ci>
<ci>O</ci>
</apply>
<apply>
<times/>
<ci>kim</ci>
<ci>I</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kom</ci>
<ci>I</ci>
</apply>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_jct</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>RI</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>j_rel_SR</ci>
<apply>
<times/>
<ci>ks</ci>
<ci>O</ci>
<apply>
<minus/>
<ci>Ca_SR</ci>
<ci>Ca_jct</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Jleak_SR">
<variable units="millimolar_per_millisecond" public_interface="out" name="j_leak_SR"/>
<variable units="per_millisecond" name="KSRleak" initial_value="5.348e-6"/>
<variable units="millimolar" public_interface="in" name="Ca_jct"/>
<variable units="millimolar" public_interface="in" name="Ca_SR"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>j_leak_SR</ci>
<apply>
<times/>
<ci>KSRleak</ci>
<apply>
<minus/>
<ci>Ca_SR</ci>
<ci>Ca_jct</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Jpump_SR">
<variable units="millimolar_per_millisecond" public_interface="out" name="j_pump_SR"/>
<variable units="millimolar_per_millisecond" name="V_max" initial_value="286e-6"/>
<variable units="dimensionless" name="Q10_SRCaP" initial_value="2.6"/>
<variable units="dimensionless" name="Q_SRCaP"/>
<variable units="millimolar" name="Kmf" initial_value="0.000246"/>
<variable units="millimolar" name="Kmr" initial_value="1.7"/>
<variable units="dimensionless" name="H" initial_value="1.787"/>
<variable units="millimolar" public_interface="in" name="Cai"/>
<variable units="millimolar" public_interface="in" name="Ca_SR"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="litre" public_interface="in" name="Vol_SR"/>
<variable units="litre" public_interface="in" private_interface="out" name="Vol_cytosol"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Q_SRCaP</ci>
<apply>
<power/>
<ci>Q10_SRCaP</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">310</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>j_pump_SR</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Q_SRCaP</ci>
<ci>V_max</ci>
<ci>Vol_cytosol</ci>
</apply>
<ci>Vol_SR</ci>
</apply>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<ci>Cai</ci>
<ci>Kmf</ci>
</apply>
<ci>H</ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_SR</ci>
<ci>Kmr</ci>
</apply>
<ci>H</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Cai</ci>
<ci>Kmf</ci>
</apply>
<ci>H</ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_SR</ci>
<ci>Kmr</ci>
</apply>
<ci>H</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ion_diffusion">
<variable units="millimole_per_millisecond" public_interface="out" name="J_Na_jct_SL"/>
<variable units="millimole_per_millisecond" public_interface="out" name="J_Na_SL_cytosol"/>
<variable units="millimole_per_millisecond" public_interface="out" name="J_Ca_jct_SL"/>
<variable units="millimole_per_millisecond" public_interface="out" name="J_Ca_SL_cytosol"/>
<variable units="dm2_per_second" name="D_Ca_jct_SL" initial_value="1.64e-6"/>
<variable units="dm2_per_second" name="D_Ca_SL_cytosol" initial_value="1.22e-6"/>
<variable units="dm2_per_second" name="D_Na_jct_SL" initial_value="1.09e-5"/>
<variable units="dm2_per_second" name="D_Na_SL_cytosol" initial_value="1.79e-5"/>
<variable units="micrometre" name="x_jct_SL" initial_value="0.5"/>
<variable units="micrometre" name="x_SL_cytosol" initial_value="0.45"/>
<variable units="cm2" name="A_jct_SL" initial_value="3.01e-6"/>
<variable units="cm2" name="A_SL_cytosol" initial_value="1.3e-4"/>
<variable units="millimolar" public_interface="in" name="Na_SL"/>
<variable units="millimolar" public_interface="in" name="Na_jct"/>
<variable units="millimolar" public_interface="in" name="Nai"/>
<variable units="millimolar" public_interface="in" name="Ca_SL"/>
<variable units="millimolar" public_interface="in" name="Cai"/>
<variable units="millimolar" public_interface="in" name="Ca_jct"/>
<variable units="litre_per_millisecond" name="j_Na_jct_SL"/>
<variable units="litre_per_millisecond" name="j_Na_SL_cytosol"/>
<variable units="litre_per_millisecond" name="j_Ca_jct_SL"/>
<variable units="litre_per_millisecond" name="j_Ca_SL_cytosol"/>
<variable units="litre_per_millisecond" name="j_Na_jct_SL_new"/>
<variable units="litre_per_millisecond" name="j_Na_SL_cytosol_new"/>
<variable units="litre_per_millisecond" name="j_Ca_jct_SL_new"/>
<variable units="litre_per_millisecond" name="j_Ca_SL_cytosol_new"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>j_Na_jct_SL</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>D_Na_jct_SL</ci>
<ci>A_jct_SL</ci>
</apply>
<ci>x_jct_SL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>j_Na_SL_cytosol</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>D_Na_SL_cytosol</ci>
<ci>A_SL_cytosol</ci>
</apply>
<ci>x_SL_cytosol</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>j_Ca_jct_SL</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>D_Ca_jct_SL</ci>
<ci>A_jct_SL</ci>
</apply>
<ci>x_jct_SL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>j_Ca_SL_cytosol</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>D_Ca_SL_cytosol</ci>
<ci>A_SL_cytosol</ci>
</apply>
<ci>x_SL_cytosol</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>j_Na_jct_SL_new</ci>
<cn cellml:units="litre_per_millisecond">1.8313e-14</cn>
</apply>
<apply>
<eq/>
<ci>j_Na_SL_cytosol_new</ci>
<cn cellml:units="litre_per_millisecond">1.6386e-12</cn>
</apply>
<apply>
<eq/>
<ci>j_Ca_jct_SL_new</ci>
<cn cellml:units="litre_per_millisecond">8.2413e-13</cn>
</apply>
<apply>
<eq/>
<ci>j_Ca_SL_cytosol_new</ci>
<cn cellml:units="litre_per_millisecond">3.7243e-12</cn>
</apply>
<apply>
<eq/>
<ci>J_Na_jct_SL</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>Na_jct</ci>
<ci>Na_SL</ci>
</apply>
<ci>j_Na_jct_SL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Na_SL_cytosol</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>Na_SL</ci>
<ci>Nai</ci>
</apply>
<ci>j_Na_SL_cytosol</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Ca_jct_SL</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>Ca_jct</ci>
<ci>Ca_SL</ci>
</apply>
<ci>j_Ca_jct_SL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Ca_SL_cytosol</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>Ca_SL</ci>
<ci>Cai</ci>
</apply>
<ci>j_Ca_SL_cytosol</ci>
</apply>
</apply>
</math>
</component>
<component name="Na_buffer">
<variable units="millimolar" public_interface="out" name="Na_SL" initial_value="8.874077316753"/>
<variable units="millimolar" public_interface="out" name="Na_jct" initial_value="8.872823559072"/>
<variable units="millimolar" public_interface="out" name="Na_SL_buf" initial_value="0.776121392467"/>
<variable units="millimolar" public_interface="out" name="Na_jct_buf" initial_value="3.557055389701"/>
<variable units="millimolar" public_interface="out" name="Nai" initial_value="8.874461106492"/>
<variable units="millimolar" name="Bmax_SL" initial_value="1.65"/>
<variable units="millimolar" name="Bmax_jct" initial_value="3.7"/>
<variable units="per_millimolar_per_millisecond" name="kon" initial_value="0.0001"/>
<variable units="per_millisecond" name="koff" initial_value="1e-3"/>
<variable units="millimole_per_millisecond" public_interface="in" name="J_Na_jct_SL"/>
<variable units="millimole_per_millisecond" public_interface="in" name="J_Na_SL_cytosol"/>
<variable units="microA_per_microF" public_interface="in" name="i_Na_jct"/>
<variable units="microA_per_microF" public_interface="in" name="i_NaCa_jct"/>
<variable units="microA_per_microF" public_interface="in" name="i_Nab_jct"/>
<variable units="microA_per_microF" public_interface="in" name="i_NaK_jct"/>
<variable units="microA_per_microF" public_interface="in" name="i_CaL_Na_jct"/>
<variable units="microA_per_microF" public_interface="in" name="i_Na_SL"/>
<variable units="microA_per_microF" public_interface="in" name="i_NaCa_SL"/>
<variable units="microA_per_microF" public_interface="in" name="i_Nab_SL"/>
<variable units="microA_per_microF" public_interface="in" name="i_NaK_SL"/>
<variable units="microA_per_microF" public_interface="in" name="i_CaL_Na_SL"/>
<variable units="litre" public_interface="in" name="Vol_SR"/>
<variable units="litre" public_interface="in" name="Vol_SL"/>
<variable units="litre" public_interface="in" name="Vol_jct"/>
<variable units="litre" public_interface="in" name="Vol_cytosol"/>
<variable units="coulomb_per_mole" public_interface="in" name="F"/>
<variable units="farad" public_interface="in" name="Cm"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="millimolar_per_millisecond" name="dNa_jct_buf"/>
<variable units="millimolar_per_millisecond" name="dNa_SL_buf"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>dNa_jct_buf</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon</ci>
<ci>Na_jct</ci>
<apply>
<minus/>
<ci>Bmax_jct</ci>
<ci>Na_jct_buf</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff</ci>
<ci>Na_jct_buf</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNa_SL_buf</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon</ci>
<ci>Na_SL</ci>
<apply>
<minus/>
<ci>Bmax_SL</ci>
<ci>Na_SL_buf</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff</ci>
<ci>Na_SL_buf</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_jct_buf</ci>
</apply>
<ci>dNa_jct_buf</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_SL_buf</ci>
</apply>
<ci>dNa_SL_buf</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_jct</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Cm</ci>
</apply>
<apply>
<plus/>
<ci>i_Na_jct</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaCa_jct</ci>
</apply>
<ci>i_Nab_jct</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaK_jct</ci>
</apply>
<ci>i_CaL_Na_jct</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Vol_jct</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<divide/>
<ci>J_Na_jct_SL</ci>
<ci>Vol_jct</ci>
</apply>
</apply>
<ci>dNa_jct_buf</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_SL</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Cm</ci>
</apply>
<apply>
<plus/>
<ci>i_Na_SL</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaCa_SL</ci>
</apply>
<ci>i_Nab_SL</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaK_SL</ci>
</apply>
<ci>i_CaL_Na_SL</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Vol_SL</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>J_Na_jct_SL</ci>
<ci>J_Na_SL_cytosol</ci>
</apply>
<ci>Vol_SL</ci>
</apply>
</apply>
<ci>dNa_SL_buf</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai</ci>
</apply>
<apply>
<divide/>
<ci>J_Na_SL_cytosol</ci>
<ci>Vol_cytosol</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_buffer">
<variable units="millimolar" public_interface="out" private_interface="out" name="Ca_SR" initial_value="0.545611267699"/>
<variable units="millimolar" public_interface="out" private_interface="out" name="Ca_SL" initial_value="0.000106395937"/>
<variable units="millimolar" public_interface="out" private_interface="out" name="Ca_jct" initial_value="0.000174843061"/>
<variable units="millimolar" public_interface="out" private_interface="out" name="Cai" initial_value="0.000087350002"/>
<variable units="millimolar" public_interface="in" private_interface="out" name="Mgi"/>
<variable units="millimolar" public_interface="out" name="Ca_SLB_SL" initial_value="0.009868629147"/>
<variable units="millimolar" public_interface="out" name="Ca_SLB_jct" initial_value="0.007780801995"/>
<variable units="millimolar" public_interface="out" name="Ca_SLHigh_SL" initial_value="0.114438990328"/>
<variable units="millimolar" public_interface="out" name="Ca_SLHigh_jct" initial_value="0.077503874257"/>
<variable units="millimolar" public_interface="out" name="Ca_Calsequestrin" initial_value="1.186496899338"/>
<variable units="millimolar" name="Bmax_SLB_SL" initial_value="0.0374"/>
<variable units="millimolar" name="Bmax_SLB_jct" initial_value="0.0046"/>
<variable units="millimolar" name="Bmax_SLHigh_SL" initial_value="0.0134"/>
<variable units="millimolar" name="Bmax_SLHigh_jct" initial_value="0.00165"/>
<variable units="millimolar" name="Bmax_Calsequestrin" initial_value="0.14"/>
<variable units="per_millimolar_per_millisecond" name="kon_SL" initial_value="100"/>
<variable units="per_millimolar_per_millisecond" name="kon_Calsequestrin" initial_value="100"/>
<variable units="per_millisecond" name="koff_SLB" initial_value="1.3"/>
<variable units="per_millisecond" name="koff_SLHigh" initial_value="30e-3"/>
<variable units="per_millisecond" name="koff_Calsequestrin" initial_value="65"/>
<variable units="microA_per_microF" public_interface="in" name="i_CaL_Ca_jct"/>
<variable units="microA_per_microF" public_interface="in" name="i_NaCa_jct"/>
<variable units="microA_per_microF" public_interface="in" name="i_Cab_jct"/>
<variable units="microA_per_microF" public_interface="in" name="i_Cap_jct"/>
<variable units="microA_per_microF" public_interface="in" name="i_CaL_Ca_SL"/>
<variable units="microA_per_microF" public_interface="in" name="i_NaCa_SL"/>
<variable units="microA_per_microF" public_interface="in" name="i_Cab_SL"/>
<variable units="microA_per_microF" public_interface="in" name="i_Cap_SL"/>
<variable units="millimolar_per_millisecond" public_interface="in" name="j_pump_SR"/>
<variable units="millimolar_per_millisecond" public_interface="in" name="j_rel_SR"/>
<variable units="millimolar_per_millisecond" public_interface="in" name="j_leak_SR"/>
<variable units="millimole_per_millisecond" public_interface="in" name="J_Ca_jct_SL"/>
<variable units="millimole_per_millisecond" public_interface="in" name="J_Ca_SL_cytosol"/>
<variable units="litre" public_interface="in" name="Vol_SR"/>
<variable units="litre" public_interface="in" private_interface="out" name="Vol_SL"/>
<variable units="litre" public_interface="in" private_interface="out" name="Vol_jct"/>
<variable units="litre" public_interface="in" private_interface="out" name="Vol_cytosol"/>
<variable units="coulomb_per_mole" public_interface="in" name="F"/>
<variable units="farad" public_interface="in" name="Cm"/>
<variable units="millisecond" public_interface="in" private_interface="out" name="time"/>
<variable units="millimolar_per_millisecond" name="dCalsequestrin"/>
<variable units="millimolar_per_millisecond" private_interface="in" name="dCa_cytosol_tot_bound"/>
<variable units="millimolar_per_millisecond" name="dCa_SLB_SL"/>
<variable units="millimolar_per_millisecond" name="dCa_SLB_jct"/>
<variable units="millimolar_per_millisecond" name="dCa_SLHigh_SL"/>
<variable units="millimolar_per_millisecond" name="dCa_SLHigh_jct"/>
<variable units="millimolar_per_millisecond" name="dCa_jct_tot_bound"/>
<variable units="millimolar_per_millisecond" name="dCa_SL_tot_bound"/>
<variable units="microA_per_microF" name="i_Ca_jct_tot"/>
<variable units="microA_per_microF" name="i_Ca_SL_tot"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>dCalsequestrin</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_Calsequestrin</ci>
<ci>Ca_SR</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Bmax_Calsequestrin</ci>
<ci>Vol_cytosol</ci>
</apply>
<ci>Vol_SR</ci>
</apply>
<ci>Ca_Calsequestrin</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_Calsequestrin</ci>
<ci>Ca_Calsequestrin</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Calsequestrin</ci>
</apply>
<ci>dCalsequestrin</ci>
</apply>
<apply>
<eq/>
<ci>dCa_SLB_SL</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_SL</ci>
<ci>Ca_SL</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Bmax_SLB_SL</ci>
<ci>Vol_cytosol</ci>
</apply>
<ci>Vol_SL</ci>
</apply>
<ci>Ca_SLB_SL</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_SLB</ci>
<ci>Ca_SLB_SL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_SLB_jct</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_SL</ci>
<ci>Ca_jct</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Bmax_SLB_jct</ci>
<ci>Vol_cytosol</ci>
</apply>
<ci>Vol_jct</ci>
</apply>
<ci>Ca_SLB_jct</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_SLB</ci>
<ci>Ca_SLB_jct</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_SLHigh_SL</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_SL</ci>
<ci>Ca_SL</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Bmax_SLHigh_SL</ci>
<ci>Vol_cytosol</ci>
</apply>
<ci>Vol_SL</ci>
</apply>
<ci>Ca_SLHigh_SL</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_SLHigh</ci>
<ci>Ca_SLHigh_SL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_SLHigh_jct</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_SL</ci>
<ci>Ca_jct</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Bmax_SLHigh_jct</ci>
<ci>Vol_cytosol</ci>
</apply>
<ci>Vol_jct</ci>
</apply>
<ci>Ca_SLHigh_jct</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_SLHigh</ci>
<ci>Ca_SLHigh_jct</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SLB_SL</ci>
</apply>
<ci>dCa_SLB_SL</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SLB_jct</ci>
</apply>
<ci>dCa_SLB_jct</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SLHigh_SL</ci>
</apply>
<ci>dCa_SLHigh_SL</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SLHigh_jct</ci>
</apply>
<ci>dCa_SLHigh_jct</ci>
</apply>
<apply>
<eq/>
<ci>dCa_jct_tot_bound</ci>
<apply>
<plus/>
<ci>dCa_SLB_jct</ci>
<ci>dCa_SLHigh_jct</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_SL_tot_bound</ci>
<apply>
<plus/>
<ci>dCa_SLB_SL</ci>
<ci>dCa_SLHigh_SL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_jct_tot</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>i_CaL_Ca_jct</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaCa_jct</ci>
</apply>
</apply>
<ci>i_Cab_jct</ci>
<ci>i_Cap_jct</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_SL_tot</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>i_CaL_Ca_SL</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaCa_SL</ci>
</apply>
</apply>
<ci>i_Cab_SL</ci>
<ci>i_Cap_SL</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SR</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>j_pump_SR</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>j_leak_SR</ci>
<ci>Vol_cytosol</ci>
</apply>
<ci>Vol_SR</ci>
</apply>
<ci>j_rel_SR</ci>
</apply>
</apply>
<ci>dCalsequestrin</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_jct</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>i_Ca_jct_tot</ci>
</apply>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<ci>Vol_jct</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<divide/>
<ci>J_Ca_jct_SL</ci>
<ci>Vol_jct</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>j_rel_SR</ci>
<ci>Vol_SR</ci>
</apply>
<ci>Vol_jct</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>j_leak_SR</ci>
<ci>Vol_cytosol</ci>
</apply>
<ci>Vol_jct</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>dCa_jct_tot_bound</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SL</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>i_Ca_SL_tot</ci>
</apply>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<ci>Vol_SL</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>J_Ca_jct_SL</ci>
<ci>J_Ca_SL_cytosol</ci>
</apply>
<ci>Vol_SL</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>dCa_SL_tot_bound</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>j_pump_SR</ci>
</apply>
<ci>Vol_SR</ci>
</apply>
<ci>Vol_cytosol</ci>
</apply>
<apply>
<divide/>
<ci>J_Ca_SL_cytosol</ci>
<ci>Vol_cytosol</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>dCa_cytosol_tot_bound</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="cytosolic_Ca_buffer">
<variable units="millimolar" public_interface="in" name="Cai"/>
<variable units="millimolar" public_interface="in" name="Mgi"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="millimolar" public_interface="out" name="Ca_TroponinC" initial_value="0.008963736337"/>
<variable units="millimolar" public_interface="out" name="Ca_TroponinC_Ca_Mg" initial_value="0.117995194438"/>
<variable units="millimolar" public_interface="out" name="Mg_TroponinC_Ca_Mg" initial_value="0.010337654274"/>
<variable units="millimolar" public_interface="out" name="Ca_Calmodulin" initial_value="0.000295961245"/>
<variable units="millimolar" public_interface="out" name="Ca_Myosin" initial_value="0.001984672275"/>
<variable units="millimolar" public_interface="out" name="Mg_Myosin" initial_value="0.137497736234"/>
<variable units="millimolar" public_interface="out" name="Ca_SRB" initial_value="0.002177112381"/>
<variable units="millimolar" name="Bmax_TroponinC" initial_value="0.07"/>
<variable units="millimolar" name="Bmax_TroponinC_Ca_Mg_Ca" initial_value="0.14"/>
<variable units="millimolar" name="Bmax_TroponinC_Ca_Mg_Mg" initial_value="0.14"/>
<variable units="millimolar" name="Bmax_Calmodulin" initial_value="0.024"/>
<variable units="millimolar" name="Bmax_Myosin_Ca" initial_value="0.14"/>
<variable units="millimolar" name="Bmax_Myosin_Mg" initial_value="0.14"/>
<variable units="millimolar" name="Bmax_SRB" initial_value="0.019"/>
<variable units="per_millimolar_per_millisecond" name="kon_TroponinC" initial_value="32.7"/>
<variable units="per_millimolar_per_millisecond" name="kon_TroponinC_Ca_Mg_Ca" initial_value="2.37"/>
<variable units="per_millimolar_per_millisecond" name="kon_TroponinC_Ca_Mg_Mg" initial_value="3e-3"/>
<variable units="per_millimolar_per_millisecond" name="kon_Calmodulin" initial_value="34"/>
<variable units="per_millimolar_per_millisecond" name="kon_Myosin_Ca" initial_value="13.8"/>
<variable units="per_millimolar_per_millisecond" name="kon_Myosin_Mg" initial_value="15.7e-3"/>
<variable units="per_millimolar_per_millisecond" name="kon_SRB" initial_value="100"/>
<variable units="per_millisecond" name="koff_TroponinC" initial_value="19.6e-3"/>
<variable units="per_millisecond" name="koff_TroponinC_Ca_Mg_Ca" initial_value="0.032e-3"/>
<variable units="per_millisecond" name="koff_TroponinC_Ca_Mg_Mg" initial_value="3.33e-3"/>
<variable units="per_millisecond" name="koff_Calmodulin" initial_value="238e-3"/>
<variable units="per_millisecond" name="koff_Myosin_Ca" initial_value="0.46e-3"/>
<variable units="per_millisecond" name="koff_Myosin_Mg" initial_value="0.057e-3"/>
<variable units="per_millisecond" name="koff_SRB" initial_value="60e-3"/>
<variable units="millimolar_per_millisecond" name="dCa_TroponinC"/>
<variable units="millimolar_per_millisecond" name="dCa_TroponinC_Ca_Mg"/>
<variable units="millimolar_per_millisecond" name="dMg_TroponinC_Ca_Mg"/>
<variable units="millimolar_per_millisecond" name="dCa_Calmodulin"/>
<variable units="millimolar_per_millisecond" name="dCa_Myosin"/>
<variable units="millimolar_per_millisecond" name="dMg_Myosin"/>
<variable units="millimolar_per_millisecond" name="dCa_SRB"/>
<variable units="millimolar_per_millisecond" public_interface="out" name="dCa_cytosol_tot_bound"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>dCa_TroponinC</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_TroponinC</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>Bmax_TroponinC</ci>
<ci>Ca_TroponinC</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_TroponinC</ci>
<ci>Ca_TroponinC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_TroponinC_Ca_Mg</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_TroponinC_Ca_Mg_Ca</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>Bmax_TroponinC_Ca_Mg_Ca</ci>
<apply>
<plus/>
<ci>Ca_TroponinC_Ca_Mg</ci>
<ci>Mg_TroponinC_Ca_Mg</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>koff_TroponinC_Ca_Mg_Ca</ci>
<ci>Ca_TroponinC_Ca_Mg</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dMg_TroponinC_Ca_Mg</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_TroponinC_Ca_Mg_Mg</ci>
<ci>Mgi</ci>
<apply>
<minus/>
<ci>Bmax_TroponinC_Ca_Mg_Mg</ci>
<apply>
<plus/>
<ci>Ca_TroponinC_Ca_Mg</ci>
<ci>Mg_TroponinC_Ca_Mg</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>koff_TroponinC_Ca_Mg_Mg</ci>
<ci>Mg_TroponinC_Ca_Mg</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_Calmodulin</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_Calmodulin</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>Bmax_Calmodulin</ci>
<ci>Ca_Calmodulin</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_Calmodulin</ci>
<ci>Ca_Calmodulin</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_Myosin</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_Myosin_Ca</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>Bmax_Myosin_Ca</ci>
<apply>
<plus/>
<ci>Ca_Myosin</ci>
<ci>Mg_Myosin</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>koff_Myosin_Ca</ci>
<ci>Ca_Myosin</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dMg_Myosin</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_Myosin_Mg</ci>
<ci>Mgi</ci>
<apply>
<minus/>
<ci>Bmax_Myosin_Mg</ci>
<apply>
<plus/>
<ci>Ca_Myosin</ci>
<ci>Mg_Myosin</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>koff_Myosin_Mg</ci>
<ci>Mg_Myosin</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_SRB</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_SRB</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>Bmax_SRB</ci>
<ci>Ca_SRB</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_SRB</ci>
<ci>Ca_SRB</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_cytosol_tot_bound</ci>
<apply>
<plus/>
<ci>dCa_TroponinC</ci>
<ci>dCa_TroponinC_Ca_Mg</ci>
<ci>dMg_TroponinC_Ca_Mg</ci>
<ci>dCa_Calmodulin</ci>
<ci>dCa_Myosin</ci>
<ci>dMg_Myosin</ci>
<ci>dCa_SRB</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_TroponinC</ci>
</apply>
<ci>dCa_TroponinC</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_TroponinC_Ca_Mg</ci>
</apply>
<ci>dCa_TroponinC_Ca_Mg</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Mg_TroponinC_Ca_Mg</ci>
</apply>
<ci>dMg_TroponinC_Ca_Mg</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Calmodulin</ci>
</apply>
<ci>dCa_Calmodulin</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Myosin</ci>
</apply>
<ci>dCa_Myosin</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Mg_Myosin</ci>
</apply>
<ci>dMg_Myosin</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SRB</ci>
</apply>
<ci>dCa_SRB</ci>
</apply>
</math>
</component>
<component name="indo_fluo_Ca_buffer_not_connected">
<variable units="millimolar" public_interface="in" name="Cai"/>
<variable units="millimolar" public_interface="in" name="Ca_SL"/>
<variable units="millimolar" public_interface="in" name="Ca_jct"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="litre" public_interface="in" name="Vol_SL"/>
<variable units="litre" public_interface="in" name="Vol_jct"/>
<variable units="litre" public_interface="in" name="Vol_cytosol"/>
<variable units="millimolar" name="Indo1" initial_value="0"/>
<variable units="millimolar" name="Fluo3" initial_value="0"/>
<variable units="millimolar" public_interface="out" name="Ca_Indo1_Cytosol" initial_value="0"/>
<variable units="millimolar" public_interface="out" name="Ca_Indo1_SL" initial_value="0"/>
<variable units="millimolar" public_interface="out" name="Ca_Indo1_jct" initial_value="0"/>
<variable units="millimolar" public_interface="out" name="Ca_Fluo3_Cytosol" initial_value="0"/>
<variable units="millimolar" public_interface="out" name="Ca_Fluo3_SL" initial_value="0"/>
<variable units="millimolar" public_interface="out" name="Ca_Fluo3_jct" initial_value="0"/>
<variable units="millimolar" name="Bmax_Indo1_Cytosol" initial_value="0.025"/>
<variable units="millimolar" name="Bmax_Indo1_SL" initial_value="0.00077"/>
<variable units="millimolar" name="Bmax_Indo1_jct" initial_value="0.00002"/>
<variable units="millimolar" name="Bmax_Fluo3_Cytosol" initial_value="0.025"/>
<variable units="millimolar" name="Bmax_Fluo3_SL" initial_value="0.00077"/>
<variable units="millimolar" name="Bmax_Fluo3_jct" initial_value="0.00002"/>
<variable units="per_millimolar2_per_millisecond" name="kon_Indo1" initial_value="100"/>
<variable units="per_millimolar2_per_millisecond" name="kon_Fluo3" initial_value="100"/>
<variable units="per_millisecond" name="koff_Indo1" initial_value="60e-3"/>
<variable units="per_millisecond" name="koff_Fluo3" initial_value="110e-3"/>
<variable units="millimolar" name="Indo1Bound"/>
<variable units="millimolar" name="Fluo3Bound"/>
<variable units="millimolar_per_millisecond" public_interface="out" name="dCa_Indo1_Cytosol"/>
<variable units="millimolar_per_millisecond" public_interface="out" name="dCa_Indo1_jct"/>
<variable units="millimolar_per_millisecond" public_interface="out" name="dCa_Indo1_SL"/>
<variable units="millimolar_per_millisecond" public_interface="out" name="dCa_Fluo3_Cytosol"/>
<variable units="millimolar_per_millisecond" public_interface="out" name="dCa_Fluo3_jct"/>
<variable units="millimolar_per_millisecond" public_interface="out" name="dCa_Fluo3_SL"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Indo1Bound</ci>
<apply>
<plus/>
<ci>Ca_Indo1_Cytosol</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Ca_Indo1_jct</ci>
<ci>Vol_jct</ci>
</apply>
<ci>Vol_cytosol</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Ca_Indo1_SL</ci>
<ci>Vol_SL</ci>
</apply>
<ci>Vol_cytosol</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Fluo3Bound</ci>
<apply>
<plus/>
<ci>Ca_Fluo3_Cytosol</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Ca_Fluo3_jct</ci>
<ci>Vol_jct</ci>
</apply>
<ci>Vol_cytosol</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Ca_Fluo3_SL</ci>
<ci>Vol_SL</ci>
</apply>
<ci>Vol_cytosol</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_Indo1_Cytosol</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_Indo1</ci>
<apply>
<minus/>
<ci>Indo1</ci>
<ci>Indo1Bound</ci>
</apply>
<ci>Cai</ci>
<apply>
<minus/>
<ci>Bmax_Indo1_Cytosol</ci>
<ci>Ca_Indo1_Cytosol</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_Indo1</ci>
<ci>Ca_Indo1_Cytosol</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_Indo1_jct</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_Indo1</ci>
<apply>
<minus/>
<ci>Indo1</ci>
<ci>Indo1Bound</ci>
</apply>
<ci>Ca_jct</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Bmax_Indo1_jct</ci>
<ci>Vol_cytosol</ci>
</apply>
<ci>Vol_jct</ci>
</apply>
<ci>Ca_Indo1_jct</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_Indo1</ci>
<ci>Ca_Indo1_jct</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_Indo1_SL</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_Indo1</ci>
<apply>
<minus/>
<ci>Indo1</ci>
<ci>Indo1Bound</ci>
</apply>
<ci>Ca_SL</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Bmax_Indo1_SL</ci>
<ci>Vol_cytosol</ci>
</apply>
<ci>Vol_SL</ci>
</apply>
<ci>Ca_Indo1_SL</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_Indo1</ci>
<ci>Ca_Indo1_SL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_Fluo3_Cytosol</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_Fluo3</ci>
<apply>
<minus/>
<ci>Fluo3</ci>
<ci>Fluo3Bound</ci>
</apply>
<ci>Cai</ci>
<apply>
<minus/>
<ci>Bmax_Fluo3_Cytosol</ci>
<ci>Ca_Fluo3_Cytosol</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_Fluo3</ci>
<ci>Ca_Fluo3_Cytosol</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_Fluo3_jct</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_Fluo3</ci>
<apply>
<minus/>
<ci>Fluo3</ci>
<ci>Fluo3Bound</ci>
</apply>
<ci>Ca_jct</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Bmax_Fluo3_jct</ci>
<ci>Vol_cytosol</ci>
</apply>
<ci>Vol_jct</ci>
</apply>
<ci>Ca_Fluo3_jct</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_Fluo3</ci>
<ci>Ca_Fluo3_jct</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_Fluo3_SL</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_Fluo3</ci>
<apply>
<minus/>
<ci>Fluo3</ci>
<ci>Fluo3Bound</ci>
</apply>
<ci>Ca_SL</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Bmax_Fluo3_SL</ci>
<ci>Vol_cytosol</ci>
</apply>
<ci>Vol_SL</ci>
</apply>
<ci>Ca_Fluo3_SL</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_Fluo3</ci>
<ci>Ca_Fluo3_SL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Indo1_Cytosol</ci>
</apply>
<ci>dCa_Indo1_Cytosol</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Indo1_SL</ci>
</apply>
<ci>dCa_Indo1_SL</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Indo1_jct</ci>
</apply>
<ci>dCa_Indo1_jct</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Fluo3_Cytosol</ci>
</apply>
<ci>dCa_Fluo3_Cytosol</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Fluo3_SL</ci>
</apply>
<ci>dCa_Fluo3_SL</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Fluo3_jct</ci>
</apply>
<ci>dCa_Fluo3_jct</ci>
</apply>
</math>
</component>
<component name="Ions_n_reversal_potentials"/>
<component name="transmembrane_currents"/>
<component name="intracellular_currents"/>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="cell">
<component_ref component="transmembrane_currents">
<component_ref component="INa">
<component_ref component="INa_m_gate"/>
<component_ref component="INa_h_gate"/>
<component_ref component="INa_j_gate"/>
</component_ref>
<component_ref component="ICaL">
<component_ref component="ICaL_d_gate"/>
<component_ref component="ICaL_f_gate"/>
<component_ref component="ICaL_fCa_gate"/>
</component_ref>
<component_ref component="ICap"/>
<component_ref component="ICab"/>
<component_ref component="IKs">
<component_ref component="IKs_Xs_gate"/>
</component_ref>
<component_ref component="IKr">
<component_ref component="IKr_Xr_gate"/>
<component_ref component="IKr_Rr_gate"/>
</component_ref>
<component_ref component="Itof">
<component_ref component="Itof_X_gate"/>
<component_ref component="Itof_Y_gate"/>
</component_ref>
<component_ref component="Itos">
<component_ref component="Itos_X_gate"/>
<component_ref component="Itos_Y_gate"/>
<component_ref component="Itos_R_gate"/>
</component_ref>
<component_ref component="IK1">
<component_ref component="IK1_K1_gate"/>
</component_ref>
<component_ref component="IKp"/>
<component_ref component="ICl_Ca"/>
<component_ref component="IClb"/>
<component_ref component="INaCa"/>
<component_ref component="INab"/>
<component_ref component="INaK"/>
</component_ref>
<component_ref component="Ions_n_reversal_potentials">
<component_ref component="Ca_buffer">
<component_ref component="cytosolic_Ca_buffer"/>
<component_ref component="indo_fluo_Ca_buffer_not_connected"/>
</component_ref>
<component_ref component="reversal_potentials"/>
<component_ref component="ion_diffusion"/>
<component_ref component="Na_buffer"/>
</component_ref>
<component_ref component="intracellular_currents">
<component_ref component="Jpump_SR"/>
<component_ref component="Jrel_SR"/>
<component_ref component="Jleak_SR"/>
</component_ref>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="INa">
<component_ref component="INa_m_gate"/>
<component_ref component="INa_h_gate"/>
<component_ref component="INa_j_gate"/>
</component_ref>
<component_ref component="ICaL">
<component_ref component="ICaL_d_gate"/>
<component_ref component="ICaL_f_gate"/>
<component_ref component="ICaL_fCa_gate"/>
</component_ref>
<component_ref component="IKs">
<component_ref component="IKs_Xs_gate"/>
</component_ref>
<component_ref component="IKr">
<component_ref component="IKr_Xr_gate"/>
<component_ref component="IKr_Rr_gate"/>
</component_ref>
<component_ref component="Itof">
<component_ref component="Itof_X_gate"/>
<component_ref component="Itof_Y_gate"/>
</component_ref>
<component_ref component="Itos">
<component_ref component="Itos_X_gate"/>
<component_ref component="Itos_Y_gate"/>
<component_ref component="Itos_R_gate"/>
</component_ref>
<component_ref component="IK1">
<component_ref component="IK1_K1_gate"/>
</component_ref>
<component_ref component="Ca_buffer">
<component_ref component="cytosolic_Ca_buffer"/>
<component_ref component="indo_fluo_Ca_buffer_not_connected"/>
</component_ref>
</group>
<connection>
<map_components component_2="environment" component_1="cell"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Na_buffer"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="INa"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Itos"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Itof"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="IKs"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="IKr"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Jrel_SR"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Ca_buffer"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="ICaL"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="INa" component_1="cell"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_Na" variable_1="i_Na"/>
</connection>
<connection>
<map_components component_2="ICaL" component_1="cell"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_CaL" variable_1="i_CaL"/>
</connection>
<connection>
<map_components component_2="Itos" component_1="cell"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_tos" variable_1="i_tos"/>
</connection>
<connection>
<map_components component_2="Itof" component_1="cell"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_tof" variable_1="i_tof"/>
</connection>
<connection>
<map_components component_2="IKs" component_1="cell"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_Ks" variable_1="i_Ks"/>
</connection>
<connection>
<map_components component_2="IKr" component_1="cell"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_Kr" variable_1="i_Kr"/>
</connection>
<connection>
<map_components component_2="IK1" component_1="cell"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_K1" variable_1="i_K1"/>
</connection>
<connection>
<map_components component_2="IKp" component_1="cell"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_Kp" variable_1="i_Kp"/>
</connection>
<connection>
<map_components component_2="INaCa" component_1="cell"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_NaCa" variable_1="i_NaCa"/>
</connection>
<connection>
<map_components component_2="INaK" component_1="cell"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_NaK" variable_1="i_NaK"/>
</connection>
<connection>
<map_components component_2="INab" component_1="cell"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_Nab" variable_1="i_Nab"/>
</connection>
<connection>
<map_components component_2="ICab" component_1="cell"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_Cab" variable_1="i_Cab"/>
</connection>
<connection>
<map_components component_2="ICl_Ca" component_1="cell"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_Cl_Ca" variable_1="i_Cl_Ca"/>
</connection>
<connection>
<map_components component_2="IClb" component_1="cell"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_Clb" variable_1="i_Clb"/>
</connection>
<connection>
<map_components component_2="ICap" component_1="cell"/>
<map_variables variable_2="i_Cap" variable_1="i_Cap"/>
</connection>
<connection>
<map_components component_2="INa" component_1="reversal_potentials"/>
<map_variables variable_2="E_Na_jct" variable_1="E_Na_jct"/>
<map_variables variable_2="E_Na_SL" variable_1="E_Na_SL"/>
</connection>
<connection>
<map_components component_2="Itos" component_1="reversal_potentials"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
</connection>
<connection>
<map_components component_2="Itof" component_1="reversal_potentials"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
</connection>
<connection>
<map_components component_2="IKr" component_1="reversal_potentials"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
</connection>
<connection>
<map_components component_2="IK1" component_1="reversal_potentials"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
</connection>
<connection>
<map_components component_2="IKp" component_1="reversal_potentials"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
</connection>
<connection>
<map_components component_2="INab" component_1="reversal_potentials"/>
<map_variables variable_2="E_Na_jct" variable_1="E_Na_jct"/>
<map_variables variable_2="E_Na_SL" variable_1="E_Na_SL"/>
</connection>
<connection>
<map_components component_2="ICab" component_1="reversal_potentials"/>
<map_variables variable_2="E_Ca_SL" variable_1="E_Ca_SL"/>
<map_variables variable_2="E_Ca_jct" variable_1="E_Ca_jct"/>
</connection>
<connection>
<map_components component_2="ICl_Ca" component_1="reversal_potentials"/>
<map_variables variable_2="E_Cl" variable_1="E_Cl"/>
</connection>
<connection>
<map_components component_2="IClb" component_1="reversal_potentials"/>
<map_variables variable_2="E_Cl" variable_1="E_Cl"/>
</connection>
<connection>
<map_components component_2="Na_buffer" component_1="reversal_potentials"/>
<map_variables variable_2="Nai" variable_1="Nai"/>
<map_variables variable_2="Na_jct" variable_1="Na_jct"/>
<map_variables variable_2="Na_SL" variable_1="Na_SL"/>
</connection>
<connection>
<map_components component_2="Ca_buffer" component_1="reversal_potentials"/>
<map_variables variable_2="Cai" variable_1="Cai"/>
<map_variables variable_2="Ca_jct" variable_1="Ca_jct"/>
<map_variables variable_2="Ca_SL" variable_1="Ca_SL"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="reversal_potentials"/>
<map_variables variable_2="Ki" variable_1="Ki"/>
<map_variables variable_2="Cli" variable_1="Cli"/>
<map_variables variable_2="Clo" variable_1="Clo"/>
<map_variables variable_2="Nao" variable_1="Nao"/>
<map_variables variable_2="Cao" variable_1="Cao"/>
<map_variables variable_2="Ko" variable_1="Ko"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
</connection>
<connection>
<map_components component_2="Ca_buffer" component_1="model_parameters"/>
<map_variables variable_2="Mgi" variable_1="Mgi"/>
<map_variables variable_2="Vol_SR" variable_1="Vol_SR"/>
<map_variables variable_2="Vol_SL" variable_1="Vol_SL"/>
<map_variables variable_2="Vol_jct" variable_1="Vol_jct"/>
<map_variables variable_2="Vol_cytosol" variable_1="Vol_cytosol"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="Cm" variable_1="Cm"/>
</connection>
<connection>
<map_components component_2="ICaL" component_1="model_parameters"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="Cao" variable_1="Cao"/>
<map_variables variable_2="Nao" variable_1="Nao"/>
<map_variables variable_2="Ko" variable_1="Ko"/>
<map_variables variable_2="Ki" variable_1="Ki"/>
</connection>
<connection>
<map_components component_2="INaCa" component_1="model_parameters"/>
<map_variables variable_2="Nao" variable_1="Nao"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="Cao" variable_1="Cao"/>
</connection>
<connection>
<map_components component_2="INaK" component_1="model_parameters"/>
<map_variables variable_2="Ko" variable_1="Ko"/>
<map_variables variable_2="Nao" variable_1="Nao"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
</connection>
<connection>
<map_components component_2="IKr" component_1="model_parameters"/>
<map_variables variable_2="Ko" variable_1="Ko"/>
</connection>
<connection>
<map_components component_2="IKs" component_1="model_parameters"/>
<map_variables variable_2="Ko" variable_1="Ko"/>
<map_variables variable_2="Ki" variable_1="Ki"/>
<map_variables variable_2="Nao" variable_1="Nao"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
</connection>
<connection>
<map_components component_2="IK1" component_1="model_parameters"/>
<map_variables variable_2="Ko" variable_1="Ko"/>
</connection>
<connection>
<map_components component_2="ICap" component_1="model_parameters"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="Vol_cytosol" variable_1="Vol_cytosol"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="Cm" variable_1="Cm"/>
</connection>
<connection>
<map_components component_2="Jpump_SR" component_1="model_parameters"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="Vol_SR" variable_1="Vol_SR"/>
<map_variables variable_2="Vol_cytosol" variable_1="Vol_cytosol"/>
</connection>
<connection>
<map_components component_2="Na_buffer" component_1="model_parameters"/>
<map_variables variable_2="Vol_SR" variable_1="Vol_SR"/>
<map_variables variable_2="Vol_SL" variable_1="Vol_SL"/>
<map_variables variable_2="Vol_jct" variable_1="Vol_jct"/>
<map_variables variable_2="Vol_cytosol" variable_1="Vol_cytosol"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="Cm" variable_1="Cm"/>
</connection>
<connection>
<map_components component_2="INa_m_gate" component_1="INa"/>
<map_variables variable_2="m" variable_1="m"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="INa_h_gate" component_1="INa"/>
<map_variables variable_2="h" variable_1="h"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="INa_j_gate" component_1="INa"/>
<map_variables variable_2="j" variable_1="j"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="ICaL_d_gate" component_1="ICaL"/>
<map_variables variable_2="d" variable_1="d"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="ICaL_f_gate" component_1="ICaL"/>
<map_variables variable_2="f" variable_1="f"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="ICaL_fCa_gate" component_1="ICaL"/>
<map_variables variable_2="fCa_SL" variable_1="fCa_SL"/>
<map_variables variable_2="fCa_jct" variable_1="fCa_jct"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="Ca_SL" variable_1="Ca_SL"/>
<map_variables variable_2="Ca_jct" variable_1="Ca_jct"/>
</connection>
<connection>
<map_components component_2="Itos_X_gate" component_1="Itos"/>
<map_variables variable_2="X_tos" variable_1="X_tos"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="Itos_Y_gate" component_1="Itos"/>
<map_variables variable_2="Y_tos" variable_1="Y_tos"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="Itos_R_gate" component_1="Itos"/>
<map_variables variable_2="R_tos" variable_1="R_tos"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="Itof_X_gate" component_1="Itof"/>
<map_variables variable_2="X_tof" variable_1="X_tof"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="Itof_Y_gate" component_1="Itof"/>
<map_variables variable_2="Y_tof" variable_1="Y_tof"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="IKs_Xs_gate" component_1="IKs"/>
<map_variables variable_2="Xs" variable_1="Xs"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="IKr_Xr_gate" component_1="IKr"/>
<map_variables variable_2="Xr" variable_1="Xr"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="IKr_Rr_gate" component_1="IKr"/>
<map_variables variable_2="Rr" variable_1="Rr"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="IK1_K1_gate" component_1="IK1"/>
<map_variables variable_2="K1_infinity" variable_1="K1_infinity"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
</connection>
<connection>
<map_components component_2="Na_buffer" component_1="ion_diffusion"/>
<map_variables variable_2="Nai" variable_1="Nai"/>
<map_variables variable_2="Na_jct" variable_1="Na_jct"/>
<map_variables variable_2="Na_SL" variable_1="Na_SL"/>
<map_variables variable_2="J_Na_jct_SL" variable_1="J_Na_jct_SL"/>
<map_variables variable_2="J_Na_SL_cytosol" variable_1="J_Na_SL_cytosol"/>
</connection>
<connection>
<map_components component_2="Ca_buffer" component_1="ion_diffusion"/>
<map_variables variable_2="Cai" variable_1="Cai"/>
<map_variables variable_2="Ca_jct" variable_1="Ca_jct"/>
<map_variables variable_2="Ca_SL" variable_1="Ca_SL"/>
<map_variables variable_2="J_Ca_jct_SL" variable_1="J_Ca_jct_SL"/>
<map_variables variable_2="J_Ca_SL_cytosol" variable_1="J_Ca_SL_cytosol"/>
</connection>
<connection>
<map_components component_2="Ca_buffer" component_1="ICl_Ca"/>
<map_variables variable_2="Ca_jct" variable_1="Ca_jct"/>
<map_variables variable_2="Ca_SL" variable_1="Ca_SL"/>
</connection>
<connection>
<map_components component_2="Na_buffer" component_1="INaK"/>
<map_variables variable_2="Nai" variable_1="Nai"/>
<map_variables variable_2="Na_jct" variable_1="Na_jct"/>
<map_variables variable_2="Na_SL" variable_1="Na_SL"/>
<map_variables variable_2="i_NaK_jct" variable_1="i_NaK_jct"/>
<map_variables variable_2="i_NaK_SL" variable_1="i_NaK_SL"/>
</connection>
<connection>
<map_components component_2="Ca_buffer" component_1="IKs"/>
<map_variables variable_2="Ca_jct" variable_1="Ca_jct"/>
<map_variables variable_2="Ca_SL" variable_1="Ca_SL"/>
</connection>
<connection>
<map_components component_2="Na_buffer" component_1="IKs"/>
<map_variables variable_2="Nai" variable_1="Nai"/>
<map_variables variable_2="Na_jct" variable_1="Na_jct"/>
<map_variables variable_2="Na_SL" variable_1="Na_SL"/>
</connection>
<connection>
<map_components component_2="Ca_buffer" component_1="ICaL"/>
<map_variables variable_2="Cai" variable_1="Cai"/>
<map_variables variable_2="Ca_SL" variable_1="Ca_SL"/>
<map_variables variable_2="Ca_jct" variable_1="Ca_jct"/>
<map_variables variable_2="i_CaL_Ca_jct" variable_1="i_CaL_Ca_jct"/>
<map_variables variable_2="i_CaL_Ca_SL" variable_1="i_CaL_Ca_SL"/>
</connection>
<connection>
<map_components component_2="Na_buffer" component_1="ICaL"/>
<map_variables variable_2="Na_SL" variable_1="Na_SL"/>
<map_variables variable_2="Na_jct" variable_1="Na_jct"/>
<map_variables variable_2="i_CaL_Na_jct" variable_1="i_CaL_Na_jct"/>
<map_variables variable_2="i_CaL_Na_SL" variable_1="i_CaL_Na_SL"/>
</connection>
<connection>
<map_components component_2="Ca_buffer" component_1="INaCa"/>
<map_variables variable_2="Cai" variable_1="Cai"/>
<map_variables variable_2="Ca_SL" variable_1="Ca_SL"/>
<map_variables variable_2="Ca_jct" variable_1="Ca_jct"/>
<map_variables variable_2="i_NaCa_jct" variable_1="i_NaCa_jct"/>
<map_variables variable_2="i_NaCa_SL" variable_1="i_NaCa_SL"/>
</connection>
<connection>
<map_components component_2="Na_buffer" component_1="INaCa"/>
<map_variables variable_2="Nai" variable_1="Nai"/>
<map_variables variable_2="Na_SL" variable_1="Na_SL"/>
<map_variables variable_2="Na_jct" variable_1="Na_jct"/>
<map_variables variable_2="i_NaCa_jct" variable_1="i_NaCa_jct"/>
<map_variables variable_2="i_NaCa_SL" variable_1="i_NaCa_SL"/>
</connection>
<connection>
<map_components component_2="Na_buffer" component_1="INa"/>
<map_variables variable_2="i_Na_jct" variable_1="i_Na_jct"/>
<map_variables variable_2="i_Na_SL" variable_1="i_Na_SL"/>
</connection>
<connection>
<map_components component_2="Na_buffer" component_1="INab"/>
<map_variables variable_2="i_Nab_jct" variable_1="i_Nab_jct"/>
<map_variables variable_2="i_Nab_SL" variable_1="i_Nab_SL"/>
</connection>
<connection>
<map_components component_2="Ca_buffer" component_1="ICab"/>
<map_variables variable_2="i_Cab_jct" variable_1="i_Cab_jct"/>
<map_variables variable_2="i_Cab_SL" variable_1="i_Cab_SL"/>
</connection>
<connection>
<map_components component_2="Ca_buffer" component_1="Jpump_SR"/>
<map_variables variable_2="Cai" variable_1="Cai"/>
<map_variables variable_2="Ca_SR" variable_1="Ca_SR"/>
<map_variables variable_2="j_pump_SR" variable_1="j_pump_SR"/>
</connection>
<connection>
<map_components component_2="Ca_buffer" component_1="ICap"/>
<map_variables variable_2="Cai" variable_1="Cai"/>
<map_variables variable_2="Ca_SL" variable_1="Ca_SL"/>
<map_variables variable_2="Ca_jct" variable_1="Ca_jct"/>
<map_variables variable_2="i_Cap_jct" variable_1="i_Cap_jct"/>
<map_variables variable_2="i_Cap_SL" variable_1="i_Cap_SL"/>
</connection>
<connection>
<map_components component_2="Ca_buffer" component_1="Jrel_SR"/>
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