You are here: Home / Exposures / Grange, Holford, Theodor, 2001 / A pharmacokinetic model to predict the PK interaction of L-dopa and benserazide in rats

Model Mathematics

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Component: environment

Component: gastrointestinal_compartment

F_H = 1 - (\frac{CL_H}{Q}) F_G = 0.244 CL_H = f_H CL_dopa_0 F_b = F_H F_G \frac{d}{d time} (A_dopa_b) = (- ka_b) A_dopa_b

Component: body_compartment_L_dopa

\frac{d}{d time} (C_dopa_b) = \frac{1}{V_dopa} (ka_b A_dopa_b F_b - (CL_dopa C_dopa_b))

Component: body_compartment_3_OMD

\frac{d}{d time} (C_OMD_b) = \frac{1}{V_OMD_b} (CL_COMT C_dopa_b - (CL_OMD_b C_OMD_b))

Component: L_dopa_clearance

CL_dopa = CL_AADC + CL_COMT + CL_REST CL_AADC = \frac{CL_AADC0}{1 + \frac{C1_M}{ki}} CL_AADC0 = CL_dopa_0 0.69 CL_COMT = CL_dopa_0 0.1 CL_REST = CL_dopa_0 0.21

Source: Derived from workspace Grange 2001 at changeset 0f29b26e482d.; This exposure was expired. A more up-to-date exposure is available, or view related resources.

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A pharmacokinetic model to predict the PK interaction of L-dopa and benserazide in rats