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Gonzalez-Heydrich, Steingard, Kohane, 1994
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A computer simulation of the hypothalamic-pituitary-adrenal axis
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Model Mathematics
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Component: environment
Component: cortisol
d
d
time
cortisol
=
k1
ACTH
+
k2
-
k3
cortisol
Component: ACTH
d
d
time
ACTH
=
k4
CRH
+
k5
-
k6
ACTH
+
k4
CRH
+
k5
Imax
cortisol
Kd
+
cortisol
Component: CRH
d
d
time
CRH
=
pulse
+
k7
-
k8
CRH
Source
Derived from workspace
Gonzalezheydrich, Steingard, Kohane, 1994
at changeset
6a57ce266fd0
.
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Creative Commons Attribution 3.0 Unported License
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A computer simulation of the hypothalamic-pituitary-adrenal axis