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Waugh, Sherratt, 2007
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Modeling the effects of treating diabetic wounds with engineered skin substitutes
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Model Mathematics
Component based math viewer is available
Component: environment
Component: phi_I
d
d
time
phi_I
=
alpha
K_T
+
k1
k2
phi_I
1.0
-
k3
phi_I
+
phi_R
+
k5
F
+
k6
C
-
d1
phi_I
Component: phi_R
d
d
time
phi_R
=
1.0
-
alpha
K_T
+
k1
k2
phi_R
1.0
-
k3
phi_I
+
phi_R
+
k5
F
+
k6
C
-
d1
phi_R
Component: T
d
d
time
T
=
k4
phi_I
+
k7
F
+
Apligraf
-
d2
T
Apligraf
=
0.0
if
time
≥
0.0
∧
time
<
28.0
0.4
if
time
≥
28.0
∧
time
<
29.0
0.0
if
time
≥
29.0
∧
time
<
35.0
0.4
if
time
≥
35.0
∧
time
<
36.0
0.0
if
time
≥
36.0
∧
time
<
42.0
0.4
if
time
≥
42.0
∧
time
<
43.0
0.0
if
time
≥
43.0
∧
time
<
49.0
0.4
if
time
≥
49.0
∧
time
<
50.0
0.0
if
time
≥
50.0
∧
time
<
56.0
0.4
if
time
≥
56.0
∧
time
<
57.0
0.0
otherwise
Component: P
d
d
time
P
=
k8
phi_I
+
phi_R
+
k9
F
+
Apligraf
-
d3
P
Apligraf
=
0.0
if
time
≥
0.0
∧
time
<
28.0
1.0
if
time
≥
28.0
∧
time
<
29.0
0.0
if
time
≥
29.0
∧
time
<
35.0
1.0
if
time
≥
35.0
∧
time
<
36.0
0.0
if
time
≥
36.0
∧
time
<
42.0
1.0
if
time
≥
42.0
∧
time
<
43.0
0.0
if
time
≥
43.0
∧
time
<
49.0
1.0
if
time
≥
49.0
∧
time
<
50.0
0.0
if
time
≥
50.0
∧
time
<
56.0
1.0
if
time
≥
56.0
∧
time
<
57.0
0.0
otherwise
Component: F
d
d
time
F
=
M_P
+
k10
F
1.0
-
k3
phi_I
+
phi_R
+
k5
F
+
k6
C
+
Apligraf
-
d4
F
Apligraf
=
0.0
if
time
≥
0.0
∧
time
<
28.0
1550.0
if
time
≥
28.0
∧
time
<
29.0
0.0
if
time
≥
29.0
∧
time
<
35.0
1550.0
if
time
≥
35.0
∧
time
<
36.0
0.0
if
time
≥
36.0
∧
time
<
42.0
1550.0
if
time
≥
42.0
∧
time
<
43.0
0.0
if
time
≥
43.0
∧
time
<
49.0
1550.0
if
time
≥
49.0
∧
time
<
50.0
0.0
if
time
≥
50.0
∧
time
<
56.0
1550.0
if
time
≥
56.0
∧
time
<
57.0
0.0
otherwise
Component: C
d
d
time
C
=
k11
F
f_T
g_C
+
Apligraf
-
d5
F
C
Apligraf
=
0.0
if
time
≥
0.0
∧
time
<
28.0
0.45
if
time
≥
28.0
∧
time
<
29.0
0.0
if
time
≥
29.0
∧
time
<
35.0
0.45
if
time
≥
35.0
∧
time
<
36.0
0.0
if
time
≥
36.0
∧
time
<
42.0
0.45
if
time
≥
42.0
∧
time
<
43.0
0.0
if
time
≥
43.0
∧
time
<
49.0
0.45
if
time
≥
49.0
∧
time
<
50.0
0.0
if
time
≥
50.0
∧
time
<
56.0
0.45
if
time
≥
56.0
∧
time
<
57.0
0.0
otherwise
Component: H
d
d
time
H
=
k12
F
+
Apligraf
-
d6
H
Apligraf
=
0.0
if
time
≥
0.0
∧
time
<
28.0
2.5
if
time
≥
28.0
∧
time
<
29.0
0.0
if
time
≥
29.0
∧
time
<
35.0
2.5
if
time
≥
35.0
∧
time
<
36.0
0.0
if
time
≥
36.0
∧
time
<
42.0
2.5
if
time
≥
42.0
∧
time
<
43.0
0.0
if
time
≥
43.0
∧
time
<
49.0
2.5
if
time
≥
49.0
∧
time
<
50.0
0.0
if
time
≥
50.0
∧
time
<
56.0
2.5
if
time
≥
56.0
∧
time
<
57.0
0.0
otherwise
Component: K_T
K_T
=
tau1
T
3.0
+
tau2
T
2.0
+
tau3
T
+
tau4
Component: M_P
M_P
=
tau1
P
3.0
+
tau2
P
2.0
+
tau3
P
+
tau4
Component: f_T
f_T
=
tau1
T
3.0
+
tau2
T
2.0
+
tau3
T
+
tau4
Component: g_C
g_C
=
tau1
C
3.0
+
tau2
C
2.0
+
tau3
C
+
tau4
Component: model_parameters
alpha
=
-
0.197
log
10
H
+
0.4407
Source
Derived from workspace
Waugh, Sherratt, 2007
at changeset
58fdb086a19f
.
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This work is licensed under a
Creative Commons Attribution 3.0 Unported License
.
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Modeling the effects of treating diabetic wounds with engineered skin substitutes
Modeling the effects of treating diabetic wounds with engineered skin substitutes
Modeling the effects of treating diabetic wounds with engineered skin substitutes
Modeling the effects of treating diabetic wounds with engineered skin substitutes