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C C There are a total of 20 entries in the algebraic variable array. C There are a total of 14 entries in each of the rate and state variable arrays. C There are a total of 24 entries in the constant variable array. C C C VOI is time in component environment (second). C STATES(1) is NatP in component NatP (molecules). C CONSTS(23) is v1 in component v1 (flux). C ALGBRC(1) is v2 in component v2 (flux). C ALGBRC(5) is v5 in component v5 (flux). C STATES(2) is MisP in component MisP (molecules). C ALGBRC(2) is v3 in component v3 (flux). C ALGBRC(4) is v4 in component v4 (flux). C ALGBRC(6) is v6 in component v6 (flux). C ALGBRC(7) is v7 in component v7 (flux). C STATES(3) is MCom in component MCom (molecules). C STATES(4) is Hsp90 in component Hsp90 (molecules). C ALGBRC(9) is v9 in component v9 (flux). C ALGBRC(17) is v16 in component v16 (flux). C ALGBRC(8) is v8 in component v8 (flux). C ALGBRC(18) is v17 in component v17 (flux). C STATES(5) is HCom in component HCom (molecules). C STATES(6) is HSF1 in component HSF1 (molecules). C ALGBRC(15) is v13 in component v13 (flux). C ALGBRC(13) is v12 in component v12 (flux). C ALGBRC(11) is v10 in component v10 (flux). C ALGBRC(12) is v11 in component v11 (flux). C STATES(7) is DiH in component DiH (molecules). C STATES(8) is TriH in component TriH (molecules). C ALGBRC(14) is v14 in component v14 (flux). C ALGBRC(16) is v15 in component v15 (flux). C STATES(9) is HSE_TriH in component HSE_TriH (molecules). C STATES(10) is HSE in component HSE (molecules). C STATES(11) is AggP in component AggP (molecules). C ALGBRC(10) is v7b in component v7b (flux). C STATES(12) is ROS in component ROS (molecules). C CONSTS(24) is v20 in component v20 (flux). C ALGBRC(3) is v21 in component v21 (flux). C STATES(13) is ATP in component ATP (molecules). C ALGBRC(19) is v18 in component v18 (flux). C ALGBRC(20) is v19 in component v19 (flux). C STATES(14) is ADP in component ADP (molecules). C CONSTS(1) is k1 in component v1 (flux). C CONSTS(2) is k2 in component v2 (second_order_rate_constant). C CONSTS(3) is k3 in component v3 (second_order_rate_constant). C CONSTS(4) is k4 in component v4 (first_order_rate_constant). C CONSTS(5) is k5 in component v5 (second_order_rate_constant). C CONSTS(6) is k6 in component v6 (second_order_rate_constant). C CONSTS(7) is k7 in component v7 (second_order_rate_constant). C CONSTS(8) is k7 in component v7b (second_order_rate_constant). C CONSTS(9) is k8 in component v8 (second_order_rate_constant). C CONSTS(10) is k9 in component v9 (first_order_rate_constant). C CONSTS(11) is k10 in component v10 (second_order_rate_constant). C CONSTS(12) is k11 in component v11 (second_order_rate_constant). C CONSTS(13) is k12 in component v12 (first_order_rate_constant). C CONSTS(14) is k13 in component v13 (first_order_rate_constant). C CONSTS(15) is k14 in component v14 (second_order_rate_constant). C CONSTS(16) is k15 in component v15 (first_order_rate_constant). C CONSTS(17) is k16 in component v16 (first_order_rate_constant). C CONSTS(18) is k17 in component v17 (second_order_rate_constant). C CONSTS(19) is k18 in component v18 (first_order_rate_constant). C CONSTS(20) is k19 in component v19 (first_order_rate_constant). C CONSTS(21) is k20 in component v20 (flux). C CONSTS(22) is k21 in component v21 (first_order_rate_constant). C RATES(1) is d/dt NatP in component NatP (molecules). C RATES(2) is d/dt MisP in component MisP (molecules). C RATES(3) is d/dt MCom in component MCom (molecules). C RATES(4) is d/dt Hsp90 in component Hsp90 (molecules). C RATES(5) is d/dt HCom in component HCom (molecules). C RATES(6) is d/dt HSF1 in component HSF1 (molecules). C RATES(7) is d/dt DiH in component DiH (molecules). C RATES(8) is d/dt TriH in component TriH (molecules). C RATES(9) is d/dt HSE_TriH in component HSE_TriH (molecules). C RATES(10) is d/dt HSE in component HSE (molecules). C RATES(11) is d/dt AggP in component AggP (molecules). C RATES(12) is d/dt ROS in component ROS (molecules). C RATES(13) is d/dt ATP in component ATP (molecules). C RATES(14) is d/dt ADP in component ADP (molecules). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 6000000 STATES(2) = 0 STATES(3) = 0 STATES(4) = 300000 STATES(5) = 5900 STATES(6) = 100 STATES(7) = 0 STATES(8) = 0 STATES(9) = 0 STATES(10) = 1 STATES(11) = 0 STATES(12) = 100 STATES(13) = 10000 STATES(14) = 1000 CONSTS(1) = 10 CONSTS(2) = 0.00002 CONSTS(3) = 50 CONSTS(4) = 0.00001 CONSTS(5) = 4e-6 CONSTS(6) = 6e-7 CONSTS(7) = 1e-7 CONSTS(8) = 1e-7 CONSTS(9) = 500 CONSTS(10) = 1 CONSTS(11) = 0.01 CONSTS(12) = 100 CONSTS(13) = 0.5 CONSTS(14) = 0.5 CONSTS(15) = 0.05 CONSTS(16) = 0.08 CONSTS(17) = 1000 CONSTS(18) = 8.02e-9 CONSTS(19) = 12 CONSTS(20) = 0.02 CONSTS(21) = 0.1 CONSTS(22) = 0.00001 CONSTS(23) = CONSTS(1) CONSTS(24) = CONSTS(21) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(2)*STATES(1)*STATES(12) ALGBRC(3) = CONSTS(22)*STATES(12) RATES(12) = (ALGBRC(1)+CONSTS(24)) - (ALGBRC(1)+ALGBRC(3)) ALGBRC(5) = CONSTS(5)*STATES(3)*STATES(13) RATES(1) = (CONSTS(23)+ALGBRC(5)) - ALGBRC(1) ALGBRC(2) = CONSTS(3)*STATES(2)*STATES(4) ALGBRC(4) = CONSTS(4)*STATES(3) RATES(3) = ALGBRC(2) - (ALGBRC(4)+ALGBRC(5)) ALGBRC(6) = CONSTS(6)*STATES(2)*STATES(13) ALGBRC(7) = CONSTS(7)*STATES(2)*STATES(2) RATES(2) = (ALGBRC(1)+ALGBRC(4)) - (ALGBRC(2)+ALGBRC(6)+ 2.00000*ALGBRC(7)) ALGBRC(9) = CONSTS(10)*STATES(5) ALGBRC(8) = CONSTS(9)*STATES(6)*STATES(4) RATES(5) = ALGBRC(8) - ALGBRC(9) ALGBRC(10) = CONSTS(8)*STATES(2)*STATES(11) RATES(11) = (ALGBRC(7)+ 2.00000*ALGBRC(10)) - ALGBRC(10) ALGBRC(15) = CONSTS(14)*STATES(7) ALGBRC(13) = CONSTS(13)*STATES(8) ALGBRC(11) = CONSTS(11)*STATES(6)*STATES(6) ALGBRC(12) = CONSTS(12)*STATES(7)*STATES(6) RATES(6) = (ALGBRC(9)+ 2.00000*ALGBRC(15)+ALGBRC(13)) - (ALGBRC(8)+ 2.00000*ALGBRC(11)+ALGBRC(12)) RATES(7) = (ALGBRC(11)+ALGBRC(13)) - (ALGBRC(12)+ALGBRC(15)) ALGBRC(14) = CONSTS(15)*STATES(10)*STATES(8) ALGBRC(16) = CONSTS(16)*STATES(9) RATES(8) = (ALGBRC(12)+ALGBRC(16)) - (ALGBRC(13)+ALGBRC(14)) RATES(10) = ALGBRC(16) - ALGBRC(14) ALGBRC(17) = CONSTS(17)*STATES(9) RATES(9) = (ALGBRC(14)+ALGBRC(17)) - (ALGBRC(16)+ALGBRC(17)) ALGBRC(18) = CONSTS(18)*STATES(4)*STATES(13) RATES(4) = (ALGBRC(5)+ALGBRC(4)+ALGBRC(9)+ALGBRC(17)) - (ALGBRC(2)+ALGBRC(8)+ALGBRC(18)) ALGBRC(19) = CONSTS(19)*STATES(14) ALGBRC(20) = CONSTS(20)*STATES(13) RATES(13) = ALGBRC(19) - (ALGBRC(5)+ALGBRC(6)+ALGBRC(18)+ALGBRC(20)) RATES(14) = (ALGBRC(5)+ALGBRC(6)+ALGBRC(18)+ALGBRC(20)) - ALGBRC(19) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(2)*STATES(1)*STATES(12) ALGBRC(3) = CONSTS(22)*STATES(12) ALGBRC(5) = CONSTS(5)*STATES(3)*STATES(13) ALGBRC(2) = CONSTS(3)*STATES(2)*STATES(4) ALGBRC(4) = CONSTS(4)*STATES(3) ALGBRC(6) = CONSTS(6)*STATES(2)*STATES(13) ALGBRC(7) = CONSTS(7)*STATES(2)*STATES(2) ALGBRC(9) = CONSTS(10)*STATES(5) ALGBRC(8) = CONSTS(9)*STATES(6)*STATES(4) ALGBRC(10) = CONSTS(8)*STATES(2)*STATES(11) ALGBRC(15) = CONSTS(14)*STATES(7) ALGBRC(13) = CONSTS(13)*STATES(8) ALGBRC(11) = CONSTS(11)*STATES(6)*STATES(6) ALGBRC(12) = CONSTS(12)*STATES(7)*STATES(6) ALGBRC(14) = CONSTS(15)*STATES(10)*STATES(8) ALGBRC(16) = CONSTS(16)*STATES(9) ALGBRC(17) = CONSTS(17)*STATES(9) ALGBRC(18) = CONSTS(18)*STATES(4)*STATES(13) ALGBRC(19) = CONSTS(19)*STATES(14) ALGBRC(20) = CONSTS(20)*STATES(13) RETURN END