You are here: Home / Exposures / Proctor, Soti, Boys, Gillespie, Shanley, Wilkinson, Kirkwood, 2005 / Modelling the actions of chaperones and their role in ageing.

Model Mathematics

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Component: environment

Component: NatP

\frac{d}{d time} (NatP) = v1 + v5 - v2

Component: MisP

\frac{d}{d time} (MisP) = v2 + v4 - (v3 + v6 + 2 v7)

Component: MCom

\frac{d}{d time} (MCom) = v3 - (v4 + v5)

Component: Hsp90

\frac{d}{d time} (Hsp90) = v5 + v4 + v9 + v16 - (v3 + v8 + v17)

Component: HCom

\frac{d}{d time} (HCom) = v8 - v9

Component: HSF1

\frac{d}{d time} (HSF1) = v9 + 2 v13 + v12 - (v8 + 2 v10 + v11)

Component: DiH

\frac{d}{d time} (DiH) = v10 + v12 - (v11 + v13)

Component: TriH

\frac{d}{d time} (TriH) = v11 + v15 - (v12 + v14)

Component: HSE_TriH

\frac{d}{d time} (HSE_TriH) = v14 + v16 - (v15 + v16)

Component: HSE

\frac{d}{d time} (HSE) = v15 - v14

Component: AggP

\frac{d}{d time} (AggP) = v7 + 2 v7b - v7b

Component: ROS

\frac{d}{d time} (ROS) = v2 + v20 - (v2 + v21)

Component: ATP

\frac{d}{d time} (ATP) = v18 - (v5 + v6 + v17 + v19)

Component: ADP

\frac{d}{d time} (ADP) = v5 + v6 + v17 + v19 - v18

Component: v1

v1 = k1

Component: v2

v2 = k2 NatP ROS

Component: v3

v3 = k3 MisP Hsp90

Component: v4

v4 = k4 MCom

Component: v5

v5 = k5 MCom ATP

Component: v6

v6 = k6 MisP ATP

Component: v7

v7 = k7 MisP MisP

Component: v7b

v7b = k7 MisP AggP

Component: v8

v8 = k8 HSF1 Hsp90

Component: v9

v9 = k9 HCom

Component: v10

v10 = k10 HSF1 HSF1

Component: v11

v11 = k11 DiH HSF1

Component: v12

v12 = k12 TriH

Component: v13

v13 = k13 DiH

Component: v14

v14 = k14 HSE TriH

Component: v15

v15 = k15 HSE_TriH

Component: v16

v16 = k16 HSE_TriH

Component: v17

v17 = k17 Hsp90 ATP

Component: v18

v18 = k18 ADP

Component: v19

v19 = k19 ATP

Component: v20

v20 = k20

Component: v21

v21 = k21 ROS

Source: Derived from workspace Proctor, 2005 at changeset 56f03f0c0dbf.; This exposure was expired. A more up-to-date exposure is available, or view related resources.

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Modelling the actions of chaperones and their role in ageing.