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  • State: Published

Covering a Broad Dynamic Range: Information Processing at the Erythropoietin Receptor

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Description
Cell surface receptors convert extracellular cues into receptor activation, thereby triggering intracellular signaling networks and controlling cellular decisions. A major unresolved issue is the identification of receptor properties that critically determine processing of ligand-encoded information. We show by mathematical modeling of quantitative data and experimental validation that rapid ligand depletion and replenishment of the cell surface receptor are characteristic features of the erythropoietin (Epo) receptor (EpoR). The amount of Epo-EpoR complexes and EpoR activation integrated over time corresponds linearly to ligand input; this process is carried out over a broad range of ligand concentrations. This relation depends solely on EpoR turnover independent of ligand binding, which suggests an essential role of large intracellular receptor pools. These receptor properties enable the system to cope with basal and acute demand in the hematopoietic system.
Owner
Hanne Nielsen <hnie010@aucklanduni.ac.nz>
URI for git clone/pull/push
http://models.cellml.org/w/hnielsen/becker_2010

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Filename Size Date Options
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becker_2010.ai 96136 2011-10-31 [browse]
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becker_2010.xul 71419 2011-10-31 [browse]
becker_2010_b.cellml 15554 2011-10-31 [browse]
becker_2010_b.session.xml 18051 2011-10-31 [browse] [run]
becker_2010_c.cellml 23911 2011-10-31 [browse]
becker_2010_c.session.xml 17159 2011-10-31 [browse] [run]
becker_2010b.ai 114405 2011-10-31 [browse]
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becker_2010b.xul 72319 2011-10-31 [browse]