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Mitochondria regulate the amplitude of simple and complex calcium oscillations

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In a mathematical model for simple calcium oscillations [Biophys. Chem. 71 (1998) 125], it has been shown that mitochondria play an important role in the maintenance of constant amplitudes of cytosolic Ca[2+] oscillations. Simple plausible rate laws for [Ca+] fluxes across the inner mitochondrial membrane have been used in this model. Here we show that it is possible to use the same rate laws as a plug-in element in other existing mathematical models and obtain the same effect on amplitude regulation. This result appears to be universal, independent of the type of model and the type of Ca oscillations. We demonstrate this on two models for spiking Ca oscillations [J. Biol. Chem. 266 (1991) 11068; Cell Calcium 14 (1993) 311] and on two recent models for bursting Ca oscillations; one of them being a receptor-operated model [Biophys. J. 79 (2000) 1188] and the other one being a store-operated model [BioSystems 57 (2000) 75].
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Hanne Nielsen <hnie010@aucklanduni.ac.nz>
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http://models.cellml.org/w/hnielsen/grubelnik_2001

Files

Filename Size Date Options
.DS_Store 6148 2011-09-26 13:51 +1300 [download]
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grubelnik_2001.xul 284241 2011-09-26 13:51 +1300 [download]
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grubelnik_2001a.cellml 18516 2011-09-26 13:51 +1300 [download]
grubelnik_2001a.session.xml 18797 2011-09-26 13:51 +1300 [download] [run]
grubelnik_2001b.cellml 23341 2011-09-26 13:51 +1300 [download]
grubelnik_2001b.session.xml 20647 2011-09-26 13:51 +1300 [download] [run]