A mathematical model of the neural regulation of phasic contractions and slow waves in the distal stomach

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Neural regulation of gastric motility occurs partly through the regulation of gastric bioelectrical slow waves and phasic contractions. A mathematical model of gastric motility regulation by enteric neurons was developed to infer the relative importance of cellular mechanisms in inhibitory neural regulation of the stomach by enteric neurons and the interaction of inhibitory and excitatory stimulation. This model was coupled to updated models of the interstitial cells of Cajal and gastric smooth muscle cells, which are responsible for generating slow waves and active tension respectively. The proposed model comprises an electrophysiological model coupling ICC and SMC via gap junctions, an active tension model bridging electrophysiology and biomechanics, and a model simulating neural regulation through nitrergic, purinergic, and cholinergic pathways, as illustrated in Figure 1. The Lees-Green small intestinal ICC model (Lees-Green et al., 2014) was reparameterised for gastric SWs. Within this model, the Ano1, NSCC, and IP3R components (Figure 1) were modified to model enteric neural regulation. The Corrias and Buist (Corrias and Buist, 2007) gastric SMC model was used to simulate intracellular SMC Ca2+ concentration and new SK and active tension components were formulated to extend this model and incorporate enteric neural regulation affecting SMC. Licensed under CC BY 4.0.

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Omkar Nitin Athavale <oath399@aucklanduni.ac.nz>

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http://models.cellml.org/workspace/b01

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