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<!--
This CellML file was generated on 20/06/2007 at 12:39:18 at a.m. using:
COR (0.9.31.649)
Copyright 2002-2007 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
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<title>Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: insights from a computational model</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
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<title>Model Status</title>
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This version of the model has been checked in COR and PCEnv and it runs - possibly replicating the published results. The units have been checked and they are consistent.
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<title>Model Structure</title>
<para>
The formation of new biological vessels requires the coordinated assembly of a proliferating syncytium of endothelial cells (EC) at different developmental stages. Angiogenesis may also be an essential mechanism of blood vessel remodelling which occurs during a diverse range of physiological processes; including tissue regeneration following injury and new vessel formation during muscle exercise. It can also occur under pathological conditions such as atherosclerosis and the vascularisation of cancerous tumours.
</para>
<para>
Matrix metalloproteinases (MMPs) are a family of enzymes responsible for the proteolytic processing of extracellular matrix (ECM) structural proteins. During angiogenesis MMPs are expressed by a single endothelial cell at the tip of the new vessel. These enzymes manifest a proteolytic activity that allows the cells of the new vessle to penetrate the ECM. In the mathematical model presented here, Karagiannis and Popel investigate the proteolytic potential of such a tip endothelial cell. The model authors suggest this model provides a foundation for future quantitative studies of angiogenesis in ECMs of different compositions. The model is described in more detail in the figure below:
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WMD-4GJVBHT-2&_user=140507&_coverDate=01%2F07%2F2006&_rdoc=12&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%236932%232006%23997619998%23612742%23FLA%23display%23Volume)&_cdi=6932&_sort=d&_docanchor=&view=c&_ct=21&_acct=C000011498&_version=1&_urlVersion=0&_userid=140507&md5=d5addc907496eab847175a55928184d0">Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: insights from a computational model</ulink>, Emmanouil D. Karagiannis and Aleksander S. Popel, 2006, <ulink url="http://www.elsevier.com/wps/find/journaldescription.cws_home/622904/description#description">
<emphasis>The Journal of Theoretical Biology</emphasis>
</ulink>, 238, 124-145. (<ulink url="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WMD-4GJVBHT-2&_user=140507&_coverDate=01%2F07%2F2006&_rdoc=12&_fmt=full&_orig=browse&_srch=doc-info(%23toc%236932%232006%23997619998%23612742%23FLA%23display%23Volume)&_cdi=6932&_sort=d&_docanchor=&view=c&_ct=21&_acct=C000011498&_version=1&_urlVersion=0&_userid=140507&md5=fc173e34bcf3e139ae316b2c34b309ef">Full text</ulink> and PDF versions of the article are available to subscribers on The Journal of Theoretical Biology website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16005020&dopt=Abstract">PubMed ID: 16005020</ulink>
</para>
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<caption>A schematic diagram of the signalling pathway.</caption>
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<vCard:Given>Matthew</vCard:Given>
<vCard:Family>McCormick</vCard:Family>
<vCard:Other/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#fe1f1b96-2b82-45e7-88ea-b96c3421133e">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value>m.mccormick@auckland.ac.nz</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a68258d6-cd5a-4466-8c53-d6b98b59858b">
<dc:creator rdf:resource="rdf:#84dc990f-40f3-4dc5-b1ef-663571e7a988"/>
<rdf:value/>
</rdf:Description>
<rdf:Description rdf:about="#bhalla_model_1999">
<bqs:reference rdf:resource="rdf:#8611abeb-7251-4c7c-b77b-d53109cb7a7e"/>
<bqs:reference rdf:parseType="Resource">
<dc:subject rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>signal transduction</rdf:li>
<rdf:li>cerebral aneurysm</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
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<cmeta:comment rdf:resource="rdf:#a68258d6-cd5a-4466-8c53-d6b98b59858b"/>
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<rdf:Description rdf:about="rdf:#9408a46f-72a6-4451-871d-2610c6385d6b">
<dc:creator rdf:resource="rdf:#d254b5df-8a75-498b-87f9-af51138e2f2c"/>
<dc:title>Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: insights from a computational model</dc:title>
<bqs:volume>238</bqs:volume>
<bqs:first_page>124</bqs:first_page>
<bqs:Journal rdf:resource="rdf:#dc3a4c12-5778-4714-ae7a-f166889677f6"/>
<dcterms:issued rdf:resource="rdf:#bbe7a8cd-622f-4fe3-8695-b62ed6f43d36"/>
<bqs:last_page>145</bqs:last_page>
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<vCard:FN/>
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<rdf:Description rdf:about="rdf:#81ca4b4c-8a9e-490b-ba87-8f3f8978b9ae">
<dc:creator rdf:resource="rdf:#1f556ae5-8d3f-4dd1-baef-886653e71c94"/>
<rdf:value>The model runs in PCEnv - but I'm not 100% sure whether or not it replicates the published results - these are displayed slightly differently.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ca9d9678-4e5b-4d68-bd15-07752a2ccb96">
<vCard:Orgname>The University of Auckland</vCard:Orgname>
<vCard:Orgunit>The Bioengineering Institute</vCard:Orgunit>
</rdf:Description>
<rdf:Description rdf:about="rdf:#8c30ab00-7bcf-4dda-8454-8ecd25b241b1">
<vCard:Given>Aleksander</vCard:Given>
<vCard:Family>Popel</vCard:Family>
<vCard:Other>S</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#aef7d271-e105-4eee-9957-52b39414ae08">
<dcterms:W3CDTF>2007-10-04T11:51:16+13:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2399e3b7-2089-4469-b7a5-0415743eb85d">
<dcterms:modified rdf:resource="rdf:#aef7d271-e105-4eee-9957-52b39414ae08"/>
<rdf:value>I ran the model in COR and corrected the units definitions such that the units are now consistent.</rdf:value>
<cmeta:modifier rdf:resource="rdf:#5f7da291-d686-4233-9373-9c12e2493c3f"/>
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<rdf:Description rdf:about="rdf:#72276d58-1f9a-49f0-86b5-3e249603e27d">
<vCard:Given>Emmanouil</vCard:Given>
<vCard:Family>Karagiannis</vCard:Family>
<vCard:Other>D</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#8611abeb-7251-4c7c-b77b-d53109cb7a7e">
<bqs:Pubmed_id>16005020</bqs:Pubmed_id>
<bqs:JournalArticle rdf:resource="rdf:#9408a46f-72a6-4451-871d-2610c6385d6b"/>
</rdf:Description>
</rdf:RDF>
</model>
