Multi_stim_experiment.cellml

Multiple stimulation experiment

In the Multiple stimulation experiment, the Excitation-contraction component is configured and parameterised with an applied multiple pulses patch clamp protocol.

You can change the parameters of stimulation in the component Vstim_para.

You can also bypass the parameters in the component model_parameters and initial_conditions and define your own parameters. We defined control_para to alter some parameters such as intracellular Na⁺ concentration, inhibition of Ca^2 + pumps control inhPump, for specific experiments.

The simulation experiment can be obtained by loading the corresponding SED-ML document into OpenCOR and executing the simulation.

The model reaction to a train of pulse potentials

We parameterise the multiple pulses patch clamp protocol to generate a train of 10 voltage pulses of 100 ms duration from a holding potential of −80 mV to a pulse potential of 0 mV, with an interval of 330 ms between the pulses. Figure [1] shows the model Ca^2 +_i to the train of pulse potentials.

Simulated model reaction to a train of pulse potentials.

The experiment setting to reproduce Figure 2 is summarized in the following:

Experiment setting.

Figure [2] shows simulations of changes in Ca^2 +_i and stress in response to pacing pulses.